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Comparative study of the sensitivity of acetylcholinesterases and cholinesterases from animal and bacterial sources to inhibition by serotonin and its derivatives

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Summary

Serotonin was found to inhibit human erythrocyte and electric-eel acetylcholinesterase activities. The serotonin amino group, free of negative charges in its vicinity and its hydroxyl group, were important for the inhibition. Serotonin precursors and several related compounds had little or no effect. Human plasma cholinesterase was also inhibited by serotonin and tryptamine. In contrast to these animal enzymes, the cholinesterase ofPseudomonas aeruginosa was refractory to serotonin and its derivatives under the same experimental conditions.

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Authors and Affiliations

  1. Department of Life Sciences, Bar-Ilan University, Ramat Gan, Israel

    N. Gilboa-Garber, Y. Katz-Bergman & A. Pinsky

Authors
  1. N. Gilboa-Garber
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  2. Y. Katz-Bergman
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  3. A. Pinsky
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Gilboa-Garber, N., Katz-Bergman, Y. & Pinsky, A. Comparative study of the sensitivity of acetylcholinesterases and cholinesterases from animal and bacterial sources to inhibition by serotonin and its derivatives. Experientia 34, 992–993 (1978). https://doi.org/10.1007/BF01915306

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