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Le systeme eau-theophylline

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Abstract

The binary system water—theophylline was studied by DTA and radiocrystallography. The slow dehydration of theophylline monohydrate was observed at room temperature at relative humidities lower than 60%, without the formation of any other hydrate. The isochoric phase diagram was established. At 78 °C, a peritectic invariant occurred, owing to decomposition of the monohydrate. The existence of only one binary compound (theophylline H2O) was confirmed by the.Tammann diagram.

Zusammenfassung

Mittels DTA und Radiokristallographie wurde das binäre System Wasser-Theophyllin untersucht. Bei einer relativen Luftfeuchtigkeit unter 60% wird bei Raumtemperatur eine langsame Dehydratation von Theophyllinemonohydrat ohne Formung anderer Hydrate beobachtet. Es wurde ein isochores Phasendiagramm entwickelt. Wegen der Zersetzung des Monohydrates tritt bei 78 °C eine peritektische Invariantheit auf. Die Existenz nur einer binären Verbindung (Theophyllin, H2O) wird mittels eines Tammanndiagrammes bekräftigt.

Резюме

Методом дифференциа льного термического анализа и радиокрист аллографии изучена двойная сист ема вода — теофиллин. П ри комнатной температу ре и относительной влажности ниже 60% наблю далась медленная дег идратация моногидрата теофилл ина без образования какого-л ибо другого гидрата. У становлена изохорная фазовая ди аграмма. При 78° наблюдалась перитек тическая инвариантн ость, вследствии разложен ия моногидрата теофи ллина. С помощью диаграммы Т эмэнна подтверждено наличие только одного двойно го соединения теофиллин-вода.

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Authors and Affiliations

  1. Chimie Physique et Minerale II, Centre D'etudes Pharmaceutiques, Universite de Paris-Sud, Rue J. B. Clement, F-92296, Chatenay-Malabry Cedex

    J. C. Rouland, J. L. Fournival & R. Ceolin

  2. Faculte de Pharmacie, Chimie Minerale, 2bis Boulevard Tonnelle, F 37042, Tours, France

    R. Ceolin

Authors
  1. J. C. Rouland
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  2. J. L. Fournival
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  3. R. Ceolin
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Rouland, J.C., Fournival, J.L. & Ceolin, R. Le systeme eau-theophylline. Journal of Thermal Analysis 35, 1643–1649 (1989). https://doi.org/10.1007/BF01912939

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  • DOI: https://doi.org/10.1007/BF01912939

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