Skip to main content
SpringerLink
Log in

Intracoronary infusion of small doses of nifedipine lowers regional myocardial O2-consumption without altering regional myocardial function

  • Original Contributions
  • Published:
Basic Research in Cardiology Aims and scope Submit manuscript

Summary

Intracoronary infusion of low doses (0.1–0.3 μg·kg−1) of nifedipine caused dose-dependent decreases in regional myocardial O2-consumption, without significant changes in any of its major global hemodynamic determinants: heart rate, left ventricular systolic and end-diastolic pressure and maxLVdP/dt. Futhermore, regional myocardial function was unaltered. It is suggested that nifedipine decreased myocardial O2-consumption by a direct effect on myocardial metabolism. Some of the possible mechanisms involved are discussed.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Vater, W., K. Schlossmann: Effects of nifedipine on the haemodynamics and the oxygen consumption of the heart in animal experiments. In: Proc. of the 3rd International Adalat Symposium, eds. A. D. Jatene and P. R. Lichtlen, p. 33. Excerpta Medica (Amsterdam-Oxford 1976).

    Google Scholar 

  2. Kaltenbach, M., W. Schultz, G. Kober: Effects of nifedipine after intravenous and intracoronary administration. Amer. J. Cardiol.22, 832–838 (1979).

    Article  Google Scholar 

  3. Serruys, P., H. N. Steward, F. Booman, R. Michels, J. H. C. Reiber, P. G. Hugenholtz: Can unstable angina pectoris be due to increased coronary vasomotor tone? Europ. Heart J.1 (suppl. B) 71–85 (1980).

    Google Scholar 

  4. Verdouw, P. D., F. J. ten Cate, P. G. Hugenholtz: Effect of nifedipine on segmental myocardial function in the anesthetized pig. Europ. J. Pharmacol.63, 209–212 (1980).

    Article  Google Scholar 

  5. Verdouw, P. D., J. M. Hartog, A. M. Rutteman: Cardiovascular and regional myocardial responses to increasing doses of the positive inotropic imidazopy. ridine AR-L 115 BS, in the absence and presence of the bradycardiac action of alinidine. Basic. Res. Cardiol., in press (1981).

  6. Zwieten, G. van, O. L. Bastiaans, B. J. Honkoop, J. A. Vogel: Video tracing of M-mode echocardiograms. In: Echocardiology, ed.: C. T. Lancée, Martinus Nijhoff Publishers bv pp. 469–766. (The Hague, Boston, London, 1979).

    Google Scholar 

  7. Katz, L. N., H. Feinberg: The relation of cardiac effort to myocardial oxygen consumption and coronary flow. Circulat. Res.6, 656–669 (1958).

    PubMed  Google Scholar 

  8. Sarnof, S. J., E. Braunwald, G. H. Welch, R. B. Case, W. N. Stainsby, R. Macruz: Hemodynamic determinants of oxygen consumption of the heart with special reference to the tension time index. Amer. J. Physiol.192, 148–156 (1958).

    PubMed  Google Scholar 

  9. Baller, D., H. J. Bretschneider, G. Hellige: A critical look at currently used indirect indices of myocardial oxygen consumption. Basic. Res. Cardiol.76, 163–181 (1981).

    Article  PubMed  Google Scholar 

  10. Krasnow, N., E. L. Rolett, P. Yurchak, W. B. Hood, R. Gorlin: Isoproterenol and cardiovascular performance. Amer. J. Med.37, 514–525 (1964).

    Article  PubMed  Google Scholar 

  11. Mjøs, O. D.: Effect of free fatty acids on myocardial function and oxygen consumption in intact dogs. J. Clin. Invest.50, 1386–1389 (1971).

    PubMed  Google Scholar 

  12. Kjekshus, J. K., O. D. Mjøs: Effect of free fatty acids on myocardial function and metabolism in the ischemic dog heart. J. Clin. Invest.51, 1767–1776 (1972).

    PubMed  Google Scholar 

  13. Simonsen, S., J. K. Kjekshus: The effect of free fatty acids on myocardial oxygen consumption during atrial pacing and catecholamine infusion in man. Circulation58, 484–491 (1978).

    PubMed  Google Scholar 

  14. Baller, D., H. G. Wolpers, J. Zipfel, A. Hoeft, G. Hellige: Unfavorable effects of ventricular pacing on myocardial energetics. Basic Res. Cardiol.76, 115–123 (1981).

    Article  PubMed  Google Scholar 

  15. Schraven, E.: Regulation des Fett- und Kohlehydratstoffwechsels des Herzens durch Carbocromen. Arzneim. Forsch.26, 197–200 (1976).

    Google Scholar 

  16. Fiedler, V. B., J. Scholtholt: Effects of carbocromene on myocardial oxygen consumption in isolated dog hearts. J. Pharmacol. Exp. Ther.217, 306–313 (1981).

    PubMed  Google Scholar 

  17. Güttler, K., W. Klaus, W. Landgraf: Carbocromen-induced alterations of the FFA/glucose-oxidation ratio in isolated guinea pig hearts. Archiv. Pharmacol.316 (suppl.), R35 abstract (1981).

    Google Scholar 

  18. Hülsmann, W. C., W. B. Elliot, E. C. Slater: The nature and mechanism of action of uncoupling agents present in mitochrome preparations. Biochim. Biophys. Acta39, 267–276 (1960).

    Article  PubMed  Google Scholar 

  19. Borst, P., P. Loos, E. J. Christ, E. C. Slater: Uncoupling activity of long-chain fatty acids. Biochim. Biophys. Acta62, 509–518 (1962).

    Article  PubMed  Google Scholar 

  20. Stam, H., W. C. Hülsmann: Intracellular origin and regulation of endogenous lipolysis in rat heart. Adv. Myocardiology, in press (1981).

  21. Lochner, A., J. C. N. Kotzé, A. J. S. Benade, G. Gevers: Mitochondrial oxidative phosphorylation in low flow hypoxia: Role of free fatty acids. J. Mol. Cell. Cardiol.10, 857–875 (1978).

    Article  PubMed  Google Scholar 

  22. Langer, G. A.: The role of calcium in the control of myocardial contractility: An update. J. Mol. Cell. Cardiol.12, 231–239 (1980).

    PubMed  Google Scholar 

  23. Dhalla, N. S., A. Ziegelhoffer, J. A. C. Harrow: Regulatory role of membrane systems in heart function. Can. J. Physiol. Pharmacol.55, 1211–1234 (1980).

    Google Scholar 

  24. Fiskum, G., A. L. Lehninger: The mechanisms and regulation of mitochondrial Ca2+ transport. Fed. Proc.39, 2432–2436 (1980).

    PubMed  Google Scholar 

  25. Challoner, D. R., D. Steinberg: Oxidative metabolism as influenced by fatty acids and epinephrine. Amer. J. Physiol.211, 897–902 (1966).

    Google Scholar 

Download references

Author information

Author notes

  1. P. D. Verdouw

    Present address: Department of Cardiovascular Research (Thoraxcenter), Erasmus University Rotterdam, P.O. Box 1738, Rotterdam, (The Netherlands)

Authors and Affiliations

  1. Department of Cardiovascular Research (Thoraxcenter), Erasmus University Rotterdam, P.O. Box 1738, Rotterdam, (The Netherlands)

    F. J. ten Cate, J. M. Hartog & M. G. Scheffer

  2. Department of Biochemistry I, Medical Faculty, Erasmus University Rotterdam, Rotterdam, (The Netherlands)

    H. Stam

Authors
  1. P. D. Verdouw
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. F. J. ten Cate
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. J. M. Hartog
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. M. G. Scheffer
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. H. Stam
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Verdouw, P.D., ten Cate, F.J., Hartog, J.M. et al. Intracoronary infusion of small doses of nifedipine lowers regional myocardial O2-consumption without altering regional myocardial function. Basic Res Cardiol 77, 26–33 (1982). https://doi.org/10.1007/BF01908128

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF01908128

Key words

Search

Navigation