Summary
We measured the functional overlap between the left arterior descending (LAD) and the rest of the coronary arteries in the dog heart. The measurements were performed by loading only the field of the LAD with133Xe gas via a close-arterial injection during normal perfusion. The LAD perfusion was then interrupted and blood was allowed to flow retrograde from the distal LAD segment. This caused a condition of extremely low flow in the tissue perfused by the LAD. Examination of the washout kinetics revealed two distinct compartments. The slow compartment accounted for 97% of the injected Xenon and was assumed to represent the central ischemic field of the LAD. The fast component accounted for only 3% of the injected tracer and was assumed to include all regions of admixture between the LAD and other coronary vessels at the lateral borders. Thus, less than 3% of the LAD's field functionally communicates with the rest of the coronary circulation.
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References
Fishbein MC, Hare CA, Gissen SA, Apadaro J, Maclean P, Maroko PR (1980) Identification and quantification of histochemical border zones during the evolution of myocardial infarction in the rat. Cardiovasc Res 14:41–49
Linder E (1966) Measurement of normal and collateral coronary blood flow by closed-arterial and intramyocardial injection of Krypton85 and Xenon133. Acta Physiol Scand Suppl 68:272–275
Volkonas PS, Malsky PM, Paul JJ, Robbins SL, Hood WB (1978) Radiographic studies in experimental myocardial infarction: Profiles of ischemic blood flow and quantification of infarct size in relation to magnitude of ischemic zone. Am J Cardiol 42:67–75
Hearse DJ, Opie LH, Katzeff IE (1977) Characterization of the “Border Zone” in acute regional ischemic in the dog. Am J Cardiol 40:716–726
Hirzel HO, Sonnenblick EH, Kirk ES (1977) Absence of a lateral border zone of intermediate creatine phosphokinase depletion surrounding a central infarct 24 hours after acute coronary occlusion in the dog. Circ Res 41:673–683
Marcus ML, Kerber RE, Ehlardt J, Abboud FM (1975) Three dimensional geometry of acutely ischemic myocardium. Circulation 52:254–263
Okun EM, Factor SM, Kirk ES (1979) End-capillary loops in the heart: An explanation for discrete myocardial infarctions without border zones. Science 206:565–567
Simson MB, Harden W, Barlow C, Harken A (1971) Visualization of the distance between perfusion and anoxia along an ischemic border. Circulation 60:1151–1155
Yellon DM, Hearse DJ, Crome R, Grannell J, Wyse REH (1981) Characterization of the lateral interface between normal and ischemic tissue in the canine heart during evolving myocardial infarction. Am J Cardiol 47:1233–1239
Meyers WW, Honig CR (1966) Amount and distribution of Rb86 transported into the myocardium from ventricular lumen. Am J Physiol 211:739–745
Hammond GL, Moggio R (1971) Function of microvascular pathways in coronary circulation. Am J Physiol 220:1463–1467
Factor SM, Sonnenblick EH, Kirk ES (1978) The histological border zone of acute myocardial infarctions: Islands or peninsulas? Am J Path 92:111–120
Barlow CH, Chance B (1976) Ischemic areas in the perfused rat heart: Measurement of NAPH fluorescence photography. Science 193:909–910
Yoshida S, Akizuki S, Downey JM (1985) Discrepancy between microsphere and diffusable tracer estimates of perfusion of ischemic myocardium during retrograde flow diversion. Am J Physiol 249:H244-H264
Harrison DG, Koyangi S, Alden B, Marcus ML (1981) Role of overlap perfusion in survival of noninfarcted risk zone following coronary occlusion. Fed Proc 40:602 (abstr)
Scheel KW, Ingram LA, Gordey R (1981) The relationship between myocardial perfusion territory and coronary flow. Fed Proc 40:A546
Chambers DE, Lee J, Downey JM (1981) Absence of overlapping circulation between adjacent circulations. The Physiologist 24:27
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Supported by Grant HL-20648 from NIH
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Downey, J.M., Yoshida, S. & Harpen, M.D. A functional estimate of overlap between adjacent coronary circulations in the dog. Basic Res Cardiol 81, 336–341 (1986). https://doi.org/10.1007/BF01907454
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DOI: https://doi.org/10.1007/BF01907454