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Is there an abluminal release of endothelium-derived relaxing factor (EDRF)?

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Summary

In superfusion bioassay systems of rabbit thoracic aorta and femoral artery ring segments as well as canine femoral artery and coronary ring segments the release of endothelium-derived relaxing factor (EDRF) was stimulated by acetylcholine in donor segments with intact endothelium. The transition of EDRF through the vessel wall (“abluminal release”) was not revealed in both bioassay systems. Externally applied acetylcholine did not reach the luminal surface of rabbit thoracic aorta but induced EDRF release in canine femoral artery segments.

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Author notes

  1. Y. P. Vedernikov

    Present address: Department of Human Cardiovascular Pathology, Cardiology Research Centre, Academy of Medical Sciences, 3-d Cherepkovskaya st. 15a, 121552, Moscow, (USSR)

Authors and Affiliations

  1. Institute of Pathophysiology, Medical Academy of Erfurt, Erfurt, (GDR)

    T. Gräser & N. Tiedt

Authors
  1. Y. P. Vedernikov
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  2. T. Gräser
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  3. N. Tiedt
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Vedernikov, Y.P., Gräser, T. & Tiedt, N. Is there an abluminal release of endothelium-derived relaxing factor (EDRF)?. Basic Res Cardiol 82, 172–177 (1987). https://doi.org/10.1007/BF01907064

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  • DOI: https://doi.org/10.1007/BF01907064

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