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Tissue protection by adrenergic blockade in the calcium paradox?

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Summary

In a graded model of the calcium paradox phenomenon (minimal and total) the presence of the β-blocker propranolol (5·10−6M) in the perfusion media (10 min prior to, during and 5 min following calcium-free perfusion) has no effect upon tissue injury. Propranolol pretreatment (three days prior to the experiments) significantly reduced the myocardial enzyme release during calcium repletion in the minimal calcium paradox. The presence of the α1 prazosin (1·10−7M) in the perfusion media (10 min prior to, during and 5 min following calcium-free perfusion) afforded no protective effects. It is concluded that the release of endogenous catecholamines may not be an important factor contributing to myocardial injury in the calcium paradox, and that consequently β- or α1-adrenergic blockade has little if any protective properties in this form of myocardial injury.

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Author notes

  1. A. N. Øksendal

    Present address: Department of Pharmacology and Toxicology, Faculty of Medicine, University of Trondheim, Eirik Jarlsgt. 10, 7000, Trondhcim, Norway

Authors and Affiliations

  1. Department of Pharmacology and Toxicology, Faculty of Medicine, University of Trondheim, Eirik Jarlsgt. 10, 7000, Trondhcim, Norway

    P. Jynge

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  1. A. N. Øksendal
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  2. P. Jynge
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Øksendal, A.N., Jynge, P. Tissue protection by adrenergic blockade in the calcium paradox?. Basic Res Cardiol 82, 138–145 (1987). https://doi.org/10.1007/BF01907061

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  • DOI: https://doi.org/10.1007/BF01907061

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