Summary
Low-flow perfusion of paced (5 Hz) rat heart Langendorff preparation with Tyrode solution for 60 min caused a reduction or disappearance of left ventricular pressure amplitude. After 60 min of low-flow perfusion myocardial concentrations of high energy phosphates, as well as the energy charged potential, were diminished while lactate accumulated. Infusion of alinidine into the perfusate at low-flow conditions, resulted in a mean concentration of 15.0±0.60 μM, and prevented the mechanical and biochemical changes of low-flow perfusion, thus indicating maintenance of acrobic metabolism under hypoxic conditions. These heart rate-independent cardioprotective effects of the “specific bradycardic” drug alinidine are discussed in light of the adenosine antagonistic actions of this compound which should prevent coronary steal.
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Streller, I., Walland, A. Antiischemic effects of alinidine in paced isolated rat hearts. Basic Res Cardiol 85, 71–77 (1990). https://doi.org/10.1007/BF01907015
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DOI: https://doi.org/10.1007/BF01907015