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Retrograde coronary blood flow after mannitol in intact anesthetized dogs

Retrograder koronarer Blutstrom nach Gaben von Mannitol bei gesunden anästhesierten Hunden

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Summary

In control dogs mannitol produced a moderate increase in coronary blood flow, a decrease in coronary vascular resistance, and a moderate increase in cardiac output. In dogs with coronary occlusion mannitol increased retrograde coronary blood flow (+25%) and collateral conductance suggesting increased blood availability to ischemic myocardium.

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Author notes

  1. G. G. Rowe

    Present address: Cardiovascular Research Laboratory, Department of Medicine, University of Wisconsin Medical School, Rm. 523, 420 N. Charter Street, 53706, Madison, Wisconsin

Authors and Affiliations

  1. Cardiovascular Research Laboratory, Department of Medicine, University of Wisconsin Medical School, Rm. 523, 420 N. Charter Street, 53706, Madison, Wisconsin

    S. Afonso, F. M. Blau & G. T. Bandow

Authors
  1. S. Afonso
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  2. F. M. Blau
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  3. G. T. Bandow
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  4. G. G. Rowe
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Additional information

With 1 figure and 3 tables

Performed during the tenure of a Pre-doctoral Fellowship, National Institutes of Health.

Performed during the tenure of a Post-doctoral Fellowship, National Institutes of Health.

This work was supported in part from grants from the National Institutes of Health, HL 5364 and HL 07754 and the Wisconsin Heart Association.

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Afonso, S., Blau, F.M., Bandow, G.T. et al. Retrograde coronary blood flow after mannitol in intact anesthetized dogs. Basic Res Cardiol 73, 329–337 (1978). https://doi.org/10.1007/BF01906515

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  • DOI: https://doi.org/10.1007/BF01906515

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