The use of nitrosamines for the induction of tumors

  • V. G. Evgrafov
  • V. P. Smirnov


Methods are described which are used for the synthesis of dimethylnitrosamine and diethylnitrosamine with a view to employing these substances for induction of tumors. The preparations were fed in drinking water to male albino rats of common breed. Eight months after the beginning of application of these preparations the experimental animals developed malignant tumors of the liver metastasizing to the lungs. The tumors are variable for their histological structure.


Internal Medicine Drinking Water Experimental Animal Malignant Tumor Nitrosamine 
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Copyright information

© Consultants Bureau 1966

Authors and Affiliations

  • V. G. Evgrafov
    • 1
  • V. P. Smirnov
    • 1
  1. 1.Department of Biochemistry, Faculty of Medicine of the Lumumba University and Human Morphology Research InstituteAcademy of Medical Sciences of the USSRMoscow

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