Skip to main content
SpringerLink
Log in

The effect of Ehrlich's ascitic carcinoma on the function of mouse thyroid

  • Oncology
  • Published:
Bulletin of Experimental Biology and Medicine Aims and scope

Summary

The ascitic fluid of Ehrlich's carcinoma contains a factor capable of an antithyroid effect, which is evidenced by a sharp decrease in the I131 absorption of the thyroid gland. This factor is thermolabile, is cooled with absolute alcohol, and is apparently of a protein or polypeptide nature. As a metabolic product of tumor cells it enters the humoral media of the body and inhibits the thyroid function. The secretion by tumor cells of a substance inhibiting the thyroid function is regarded as a specific manifestation of one of the mechanisms by which the tumor influences a definite system in the body. This substance cannot be attributed to the group of “toxohormones” because, as distinct from the latter, which has thermal stability, it is a thermolabile compound.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

Literature Cited

  1. B. V. Aleshin and N. G. Tsarikovskaya, Medichn. Zh., Vol. 24, No. 6 (1954), p. 23.

    Google Scholar 

  2. V. I. Arkhipenko and A. P. Vorona, Proc. 2nd All-Union Conf. of Endocrinologists, Moscow (1962), p. 37.

  3. L. S. Gitkina, Zdravookhr. Belorussii, No. 6 (1960), p. 46.

    Google Scholar 

  4. L. F. Larionov, Cancer and the Endocrine System, Leningrad (1938).

  5. V. I. Yakovleva, Arkh. Pat., No. 6 (1958), p. 67.

    Google Scholar 

  6. J. L. Claus et al., Acta Endocr., Vol. 40 (1962), p. 584.

    PubMed  Google Scholar 

  7. D. Grinshtein, Biochemistry of Cancer, Moscow (1951).

  8. R. D. Liechty, R. D. Hodges, J. Burket, J. A. M. A., Vol. 183 (1963), p. 30.

    PubMed  Google Scholar 

  9. V. Nakahara and F. Fukuoka, In: Progress in Cancer Study, Moscow, Vol. 5, Moscow (1960), p. 291.

  10. K. G. Scott and M. B. Daniels, Cancer Res., Vol. 16 (1956), p. 784.

    PubMed  Google Scholar 

  11. K. G. Scott, W. A. Reilly, and G. L. Searle, Cancer, Vol. 13, Philadelphia (1960), p. 1261.

    PubMed  Google Scholar 

  12. C. D. Stevens, P. D. Meiken, P. M. Quinlau et al., Cancer Res., Vol. 10 (1950), p. 155.

    PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Histology, the Dnepropetrovsk Medical Institute, Dnepropetrovsk, USSR

    V. I. Arkhipenko

Authors
  1. V. I. Arkhipenko
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Arkhipenko, V.I. The effect of Ehrlich's ascitic carcinoma on the function of mouse thyroid. Bull Exp Biol Med 61, 573–575 (1966). https://doi.org/10.1007/BF01892458

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF01892458

Keywords

Search

Navigation