Abstract
Electronmicroscopic observations are reported on the effects of orally administered aspirin on the rat fastric mucosa to establish the cytotoxic events that occur during the early stages of the development of gastric damage induced by this drug. The results show that aspirin, apart from damaging superficial mucous cells, causes selective damage to the acid-secreting parietal cells located deep in the fundic mucosa. It is suggested that the selective accumulation of salicylates in the parietal cells may account for the specific cytotoxic actions of aspirin on these cells.
Similar content being viewed by others
References
Brune, K., Graf, P., Rainsford, K. D.: A pharmacokinetic approach to the understanding of therapeutic effects and side effects of salicylates. In: Proceedings of a Symposium on “Aspirin and Related Drugs: Their actions and uses”. Hobart 1976 (K. D. Rainsford, K. Brune, M. W. Whitehouse, eds.). Agents and Actions, Suppl.1, 9–26 (1977)
Brune, K., Schweitzer, A., Eckert, H.: Parietal cells of the stomach trap salicylates during absorption. Biochem. Pharmacol.26, 1735–1740 (1977)
Cooke, A. R.: Drugs and gastric damage. Drugs,11, 36–44 (1976)
Harford, D. J., Smith, M. J. H.; The effect of sodium salicylate on the release of acid phosphatase activity from a rat liver lysosomes. J. Pharm. Pharmacol.22, 578–583 (1970)
Hingson, D. J., Ito, S.: Effect of aspirin and related compounds on the fine structure of mouse gastric mucosa. Gastroenterology (Basel)61, 156–177 (1971)
Inglot, A. D., Wolna, E.: Reactions of non-steroid anti-inflammatory drugs with the eryhtrocyte membrane. Biochem. Pharmacol.17, 269–279 (1968)
Levitan, H., Barker, J. L.: Salicylate: A structure activity study of its effects on membrane permeability. Science,176, 1423–1425 (1972)
McLaughlin, S.: Salicylates and phospholipid bilayer membranes. Nature (Lond.)243, 234–237 (1973)
Pfeiffer, C. J., Weibel, J.: The gastric mucosal responses to acetysalicylic acid in the ferret. An ultrastructural study. Amer. J. dig. Dis.,18, 834–846 (1973)
Rainsford, K. D.: The biochemical pathology of aspirin induced gastric damage. Agents and actions5, 326–344 (1975a)
Rainsford, K. D.: Electronmicroscopic observations on the effects of orally administered aspirin and aspirin-bicarbonate mixtures on the development of gastric mucosal damage in the rat. Gut16, 514–527 (1975b)
Rainsford, K. D.: The comparative gastric ulcerogenic activities of non-steroid anti-inflammatory drugs. Agents and Actions7, 573–577 (1977)
Rainsford, K. D., Brune, K.: Role of the parietal cell in gastric damage induced by aspirin and related drugs: Implications for safer therapy. Med. J. Aust.1, 881–883 (1976)
Schweitzer, A., Brune, K.: Salicylic acid and proquazone: The differences in absorption and biodistribution explain their different profile of side-effects. Persp. in Inflammation (in press) (1978)
Tanaka, K., Iizuka, Y.: Suppression of enzyme release from isolated rat liver lysosomes by non-steroidal anti-inflammatory drugs. Biochem. Pharmacol.17, 2023–2032 (1968)
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Rainsford, K.D., Brune, K. Selective cytotoxic actions of aspirin on parietal cells: A principal factor in the early stages of aspirin-induced gastric damage. Arch Toxicol 40, 143–150 (1978). https://doi.org/10.1007/BF01891969
Received:
Issue Date:
DOI: https://doi.org/10.1007/BF01891969