Abstract
Subcutaneous administration of bismuth, both single and multiple, resulted in deposition of this metal mainly in the kidneys which contained over 50% of the ‘accessible pool’ of bismuth. In the kidneys bismuth was bound mainly by the soluble fraction in which it was complexed with a protein of molecular weight of about 7000. Multiple administration of bismuth increased the level of this protein. Selenite administration brought about an increase in the ‘accessible pool’ of bismuth, probably due to a drop in excretion, and also changes in the organ distribution of this metal. The retention in the kidneys was diminished while those in the liver and in other tissues were augmented. These changes were accompanied by a change in the chemical form of bismuth present in the kidneys manifested by the total disappearance of the protein complex of molecular weight of 7000. The increased synthesis of this protein due to bismuth administration was not abolished completely.
Zusammenfassung
Nach einmaliger und wiederholter subkutaner Verabreichung wurde Wismut zu mehr als 50% der „erreichbaren Menge” in den Nieren gefunden. Es war dort vorwiegend in der löslichen Frakion und in großem Umfang an einen Eiweißstoff vom Molekulargewicht 7000 gebunden. Bei wiederholter erabreichung von Wismut wurde auch dieser Eiweißstoff vermehrt gefunden. Die gleichzeitige Verabreichung von Selen erhöhte die „verfügbare Menge” von Wismut, wahrscheinlich wegen eingeschränkter Ausscheidung. Zugleich wurden Unterschiede in der Organverteilung von Wismut festgestellt. Der Anteil in den Nieren wirde geringer und derjenige in Leber und sonstigen. Organen größer. Der Eiweißkomplex mit dem Molekulargewicht 7000 verschwand gänzlich. Die durch Wismut stimulierte Synthese dieses Eiweißstoffes wirde aber nicht ganz verhindert.
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Szymańska, J.A., Zychowicz, M., Zelazowski, A.J. et al. Effect of selenium on the organ distribution and binding of bismuth in rat tissues. Arch Toxicol 40, 131–141 (1978). https://doi.org/10.1007/BF01891968
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DOI: https://doi.org/10.1007/BF01891968