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Decreased plasma levels of cyclic GMP in patients with chest pain and angiographically normal coronary arteries

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Summary

Plasma levels of cyclic nucleotides were determined by radioimmunoassy in patients with (1) angina-like chest pain and normal coronary arteries (suspected spasm angina), (2) exercise-induced angina, and (3) heart diseases other than angina pectoris, as well as in (4) normal subjects. The concentration of cyclic GMP in plasma was significantly lower (by at least three-fold) in patients with suspected spasm angina, as compared with the other groups. No statistically significant difference in the plasma levels of cAMP was observed between the different patient groups. The low cGMP levels in plasma from patients with angina-like chest pain and normal coronary arteries might be an indication of a defect in the vasculature, making it more sensitive to contractile stimuli.

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Abbreviations

cAMP, cyclic AMP:

Cyclic adenosine 3′,5′-monophosphate

cGMP, cyclic GMP:

Cyclic guanosine 3′,5′-monophosphate

ECG:

Electrocardiogram

EDTA:

Ethylenediamine tetraacetic acid

EDRF:

Endothelium-derivied relaxing factor

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Authors and Affiliations

  1. Department of Clinical Pharmacology, University Hospital, Linköping, Sweden

    J. Ahlner

  2. Department of Pharmacology, University Hospital, Linköping, Sweden

    R. G. G. Andersson & K. L. Axelsson

  3. Department of Internal Medicine, University Hospital, Linköping, Sweden

    B. Bergdahl, U. Dahlström & E. Swahn

Authors
  1. J. Ahlner
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  2. R. G. G. Andersson
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  3. K. L. Axelsson
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  4. B. Bergdahl
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  5. U. Dahlström
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  6. E. Swahn
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Ahlner, J., Andersson, R.G.G., Axelsson, K.L. et al. Decreased plasma levels of cyclic GMP in patients with chest pain and angiographically normal coronary arteries. Klin Wochenschr 66, 494–497 (1988). https://doi.org/10.1007/BF01876171

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  • DOI: https://doi.org/10.1007/BF01876171

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