Summary
The muscle fiber stands alongside the red blood cell and the giant axon as one of the three classical cell types that have had major application in investigating ion transport processes in cell membranes. Of these three cell types, the muscle fiber was the first to provide definite evidence for a sodium pump. The ability of the sodium pump to produce an electrical potential difference across the cell membrane was also first demonstrated in muscle fibers. This important property of the sodium pump is now known to have physiological significance in many other types of cells.
In this review, electrolyte transport investigations in skeletal muscle are traced from their inception to the current state of the field. Applications of major research techniques are discussed and key results are summarized. An overview of electrolyte transport in muscle, this article emphasizes relationships between the muscle fiber membrane potential and ionic transport processes.
Similar content being viewed by others
References
Adrian, R.H. 1956.J. Physiol. (London) 133:631–658
Adrian, R.H. 1960.J. Physiol. (London) 151:154–185
Adrian, R.H. 1961.J. Physiol. (London) 156:623–632
Adrian, R.H. 1964.J. Physiol. (London) 175:134–159
Adrian, R.H., Slayman, C.L. 1966.J. Physiol. (London) 184:970–1014
Armstrong, C.M., Bezanilla, F.M., Horowicz, P. 1972.Biochim. Biophys. Acta 267:605–608
Asano, Y. 1978.Experientia Suppl. 32:199–203
Ashley, C.C., Ellory, J.C., Hainaut, K. 1974.J. Physiol. (London) 242:255–272
Beaugé, L. 1975.J. Physiol. (London) 246:397–420
Beaugé, L.A., Medici, A., Sjodin, R.A. 1973.J. Physiol. (London) 228:1–11
Beaugé, L.A., Ortiz, O. 1970.J. Exptl. Zool. 174:309–315
Beaugé, L.A., Ortiz, O. 1972.J. Physiol. (London) 226:675–697
Beaugé, L.A., Sjodin, R.A. 1968.J. Physiol. (London) 194:105–123
Beaugé, L.A., Sjodin, R.A., 1968.J. Gen. Physiol. 52:408–423
Beaugé, L.A., Sjodin, R.A. 1976.J. Physiol. (London) 263:383–403
Beaugé, L.A., Sjodin, R.A., Ortiz, O. 1975.Biochim. Biophys. Acta 389:189–193
Bianchi, C.P., Shanes, A.M. 1959.J. Gen. Physiol. 42:803–815
Biron, R., Burger, A., Chinet, A., Clausen, T., Dubois-Ferriere R. 1979.J. Physiol. (London) 297:47–60
Bittar, E.E. 1966.J. Physiol. (London) 187:81–103
Bolingbroke, V., Harris, E.J., Sjodin, R.A. 1961.J. Physiol. (London) 157:289–305
Bolton, T.B., Vaughan-Jones, R.D. 1977.J. Physiol. (London) 270:801–833
Boyle, P.J., Conway, E.J. 1941.J. Physiol. (London) 100:1–63
Brinley, F.J., Jr. 1968.J. Gen. Physiol. 51:445–477
Brinley, F.J., Jr., Mullins, L.J. 1968.J. Gen. Physiol. 52:181–211
Brodal, B.P., Jebens, E., Öy, V., Iverson, O.J. 1974.Nature (London) 249:41–43
Caputo, C., Bolanos, P. 1978.J. Membrane Biol. 41:1–14
Carey, M.J., Conway, E.J. 1954.J. Physiol. (London) 125:232–250
Clausen, T., Flatman, J.A., 1977.J. Physiol. (London) 270:383–414
Clausen, T., Hansen, O. 1974.Biochim. Biophys. Acta 345:387–404
Clausen, T., Hansen, O. 1977.J. Physiol. (London) 270:415–430
Clausen, T., Kohn, P.G. 1977.J. Physiol. (London) 265:19–42
Conway, E.J., 1957.Physiol. Rev. 37:84–132
Conway, E.J. 1960.Nature (London) 187:394–396
Conway, E.J., Hingerty, D. 1948.Biochem. J. 42:372–376
Conway, E.J., Kernan, R.P., Zadunaisky, J.A. 1961.J. Physiol. (London) 155:263–279
Cosmos, E., Harris, E.J. 1961.J. Gen. Physiol. 44:1121–1130
Creese, R. 1954.Proc. R. Soc. London B. 142:497–513
Creese R. 1968.J. Physiol. (London) 197:255–278
Creese, R., Neil, M.W., Stephenson, G. 1956.Trans. Faraday Soc. 52:1022–1032
Cross, S.B., Keynes, R.D., Rybová, R. 1965.J. Physiol. (London) 181:865–880
Dean, R.B., 1941.Biol. Symp. 3:331–348
Desmedt, J.E. 1953.J. Physiol. (London) 121:191–205
Dydynska, M., Harris, E.J. 1966.J. Physiol. (London) 182:92–109
Ebashi, S. 1958.Arch. Biochem. Biophys. 76:410–423
Edwards, C., Harris, E.J. 1957.J. Physiol. (London) 135:567–580
Edwards, C., Harris, E.J., Nishie, K. 1957.J. Physiol. (London) 135:560–566
Eisenman, G. 1961.In: Symposium on Membrane Transport and Metabolism. A. Kleinzeller and A. Kotyk, editors. pp. 163–179. Academic Press, New York
Erlij, D. 1980.Adv. Physiol. Sci. 5:329–340
Erlij, D., Grinstein, S. 1976.J. Physiol. (London) 259:13–31
Erlij, D., Leblanc, G. 1971.J. Physiol. (London) 214:327–347
Erlij, D., Fleming, M., Grinstein, S., Shen, W.K. 1979.J. Physiol. (London) 300:15P-16P
Flatman, J.A., Clausen, T. 1979.Nature (London) 281:580–581
Frazier, H.S., Keynes, R.D. 1959.J. Physiol. (London) 148:362–378
Frumento, A.S. 1965.Science 147:1442–1443
Garrahan, P.J., Glynn, I.M. 1967.J. Physiol. (London) 192:189–216
Gavryck, W.A., Moore, R.D., Thompson,R.C. 1975.J. Physiol. (London) 252:43–58
Grinnell, A.D., Brazier, M.A.B., editors. 1981. The Regulation of Muscle Contraction, Excitation-Contraction Coupling Academic Press, New York
Hagiwara, S., Gruener, R., Hayashi, H., Sakata, H., Grinnell, A.D. 1968.J. Gen. Physiol. 52:773–792
Harris, E.J. 1950.Trans. Faraday Soc. 46:872–882
Harris, E.J. 1957.J. Gen. Physiol. 41:169–195
Harris, E.J. 1958.J. Physiol. (London) 141:351–365
Harris, E.J. 1963.J. Physiol. (London) 166:87–109
Harris, E.J., Burn, G.P. 1949.Trans. Faraday Soc. 45:508–528
Harris, E.J., Sjodin, R.A. 1961.J. Physiol. (London) 155:221–245
Harris, E.J., Steinbach, H.B. 1956.J. Physiol. (London) 133:385–401
Hasselbach, W. 1964.Prog. Biophys. Mol. Biol. 14:167–222
Hays, E.T., Dwyer, T.M., Horowicz, P., Swift, J.G. 1974.Am. J. Physiol. 227:1340–1347
Hegyvary, C., Post, R.L. 1971.J. Biol. Chem. 246:5234–5240
Henderson, E.G., Volle, R.S. 1972.J. Pharmacol. Exp. Ther. 183:356–369
Heppel, L.A. 1939.Am. J. Physiol. 127:385–392
Hodgkin, A.L. 1958.Proc. R. Soc. London B 148:1–37
Hodgkin, A.L., Horowicz, P. 1959.J. Physiol. (London) 145:405–432
Hodgkin, A.L., Horowicz, P. 1959.J. Physiol. (London) 148:127–160
Hodgkin, A.L., Katz, B. 1949.J. Physiol. (London) 108:37–77
Hodgkin, A.L., Keynes, R.D. 1955.J. Physiol. (London) 128:61–88
Horowicz, P., Gage, P.W., Eisenberg, R.S. 1968.J. Gen. Physiol. 51:193S-203S
Horowicz, P., Gerber, C. 1965.J. Gen. Physiol. 48:489–514
Horowicz, P., Gerber, C.J. 1965.J. Gen. Physiol. 48:515–525
Hutter, O.F., Warner, A.E. 1967.J. Physiol. (London) 189:403–425
Hutter, O.F., Warner, A.E. 1967.J. Physiol. (London) 189:427–443
Hutter, O.F., Warner, A.E. 1967.J. Physiol. (London) 189:445–460
Jenerick, H.P., Gerard, R.W. 1953.J. Cell. Comp. Physiol. 42:79–102
Johnson, J.A., 1956.Am. J. Physiol. 187:328–332
Katz, B. 1949.Arch. Sci. Physiol. 3:285–300
Kennedy, B.G., DeWeer, P. 1976.J. Gen. Physiol. 68:405–420
Kennedy, B.G., DeWeer, P. 1977.Nature (London) 268:165–167
Kennedy, B.G., DeWeer, P. 1977.Biophys. J. 17:154a
Kernan, R.P. 1960.Nature (London) 185:471
Kernan, R.P. 1962.Nature (London) 193:986–987
Kernan, R.P. 1962.J. Physiol. (London) 162:129–137
Kernan, R.P. 1963.Nature (London) 200:474–475
Kernan, R.P. 1963.J. Physiol. (London) 169:862–878
Keynes, R.D. 1954.Proc. R. Soc. London B 142:359–382
Keynes, R.D. 1965.J. Physiol. (London) 178:305–325
Keynes, R.D., Rybová, R. 1963.J. Physiol. (London) 168:58P
Keynes, R.D., Steinhardt, R.A. 1968.J. Physiol. (London) 198:581–599
Keynes, R.D., Swan, R.C., 1959.J. Physiol. (London) 147:591–625
Keynes, R.D., Swan, R.C. 1959.J. Physiol. (London) 147:626–638
Kitasato, H., Sato, S., Murayama, K., Nishio, K. 1980.Jpn. J. Physiol. 30:115–130
Lev, A.A., 1964.Nature (London) 201:1132–1134
Ling, G., Gerard, R.W. 1949.J. Cell Comp. Physiol. 34:383–396
Ling, G., Gerard, R.W. 1950.Nature (London) 165:113–114
Lüttgau, H.C., Spiecker, W. 1979.J. Physiol. (London) 296:411–429
Matchett, P.A., Johnson, J.A. 1954.Fed. Proc. 13:384
McClellan, G., Gonzalez-Serratos, H., Horowicz, P. 1974.Fed. Proc. 33:1458a
Moore, R.D., 1973.J. Physiol. (London) 232:23–45
Moore, R.D., Rabovsky, J.L. 1979.Am. J. Physiol. 236:C249-C254
Mullins, L.J. 1959.J. Gen. Physiol. 42:817–829
Mullins, L.J. 1960.J. Gen. Physiol. 43:105–117
Mullins, L.J., Awad, M.Z. 1965.J. Gen. Physiol. 48:761–775
Mullins, L.J., Brinley, F.J. Jr. 1967.J. Gen. Physiol. 50:2333–2355
Mullins, L.J., Frumento, A.S. 1963.J. Gen. Physiol. 46:629–654
Mullins, L.J., Moore, R.D. 1960.J. Gen. Physiol. 43:759–773
Mullins, L.J., Noda, K. 1963.J. Gen. Physiol. 47:117–132
Nastuk, W., Hodgkin, A.L., 1950.J. Cell Comp. Physiol. 35:39–73
Ridgway, E.B., Ashley, C.C. 1967.Biochem. Biophys. Res. Commun. 29:229–234
Russell, J.M., Blaustein, M.P. 1974.J. Gen. Physiol. 63:144–167
Sjodin, R.A. 1959.J. Gen. Physiol. 42:983–1003
Sjodin, R.A. 1961.J. Gen. Physiol. 44:929–962
Sjodin, R.A. 1965.J. Gen. Physiol. 48:777–795
Sjodin, R.A. 1965.J. Cell Comp. Physiol. 66:27–32
Sjodin, R.A. 1971.J. Gen. Physiol. 57:164–187
Sjodin, R.A., Beaugé, L.A. 1968.J. Gen. Physiol. 52:389–407
Sjodin, R.A., Beaugé, L.A. 1973.J. Gen. Physiol. 61:222–250
Sjodin, R.A., Gold, S. 1981. Abstracts, VII International Biophysics Congress, Mexico City p. 174
Sjodin, R.A., Henderson, E.G. 1964.J. Gen. Physiol. 47:605–638
Sjodin, R.A., Ortiz, O. 1975.J. Gen. Physiol. 66:269–286
Skou, J.C. 1960.Biochim. Biophys. Acta 42:6–23
Smillie, L.B., Manery, J.F. 1960.Am. J. Physiol. 198:67–77
Sperelakis, N., Schneider, M.F., Harris, E.J., 1967.J. Gen. Physiol. 50:1565–1583
Steinbach, H.B. 1940.J. Biol. Chem. 133:695–701
Steinbach, H.B. 1961.J. Gen. Physiol. 44:1131–1142
Stephenson, E.W. 1978.J. Gen. Physiol. 71:411–430
Ussing, H.H. 1949.Acta Physiol. Scand. 19:43–56
Ussing, H.H. 1949.Physiol. Rev. 29:127–155
Whittam, R. 1962.Biochem. J. 84:110–118
Winegrad, S. 1968.J. Gen. Physiol. 51:65–83
Zierler, K.L. 1959.Am. J. Physiol. 197:515–523
Zierler, K.L., 1960.Am. J. Physiol. 198:1066–1070
Zierler, K.L. 1972.In: Handbook of Physiology, Section 7: Endocrinology. Williams & Wilkins, Baltimore
Zierler, K.L., Rogus, E., Hazlewood, C.F. 1966.J. Gen. Physiol. 49:433–456
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Sjodin, R.A. Transport of electrolytes in muscle. J. Membrain Biol. 68, 161–178 (1982). https://doi.org/10.1007/BF01872262
Received:
Issue Date:
DOI: https://doi.org/10.1007/BF01872262