Abstract
Ion gradients across the skeletal muscle membrane undergo pronounced changes during intense muscle contractions. These changes influence excitability and muscle performance. The ion changes are counteracted by the activity of the Na, K-pump. Regulation of the Na, K-pump in association with muscle activity is therefore important for muscle function. This short review focuses on exercise-induced acute changes in Na, K-pump activity in skeletal muscles. The Na, K-pump is dependent on the intracellular Na+ concentration, which is influenced by muscle activity. Exercise changes the number of functional pumps in the outer membrane (translocation). In addition, the Na, K-pump activity is influenced by hormones, purines, nitric oxide and exercise-induced oxidative stress, which increases subunit S-glutathionylation. Some of these regulatory changes are mediated by changes in the interaction between the Na, K-pump α and β subunits and the regulatory protein phospholemman (FXYD1). Thus, exercise-induced acute regulation of the Na, K-pump in skeletal muscles is a multifactorial process.
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Juel, C. (2016). Exercise-Induced Regulation of the Na, K-Pump in Skeletal Muscles. In: Chakraborti, S., Dhalla, N. (eds) Regulation of Membrane Na+-K+ ATPase. Advances in Biochemistry in Health and Disease, vol 15. Springer, Cham. https://doi.org/10.1007/978-3-319-24750-2_21
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DOI: https://doi.org/10.1007/978-3-319-24750-2_21
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