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Reversal by cimetidine of histamine-induced inhibition of true chemotaxis in neutrophil polymorphonuclears

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Research in Experimental Medicine

Summary

The effects of histamine and cimetidine on neutrophil locomotion were studied in vitro in experimental conditions able to dissociate random from truly directional motility. Histamine 10−4 mol/l inhibited the true chemotactic response. Cimetidine was able to reverse the histamine-induced inhibition of true chemotaxis.

Since histamine-induced inhibition of neutrophil chemotaxis may play a role in allergic patients with repeated infections, and since cimetidine has been shown to enhance cell-mediated immunity in vivo, often impaired in such cases, the use of cimetidine is suggested for the prevention of recurrences in these patients.

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References

  1. Anderson R, Glover A, Rabson AR (1977) The in vitro effects of histamine and metiamide on neutrophil motility and their relationship to intracellular cyclic nucleotide levels. J Immunol 118:1690–1696

    PubMed  Google Scholar 

  2. Avella J, Madsen JE, Binder HJ, Askenase PW (1978) Effect of histamine H2-receptor antagonists on delayed hypersensitivity. Lancet 1:624–626

    Article  PubMed  Google Scholar 

  3. Bodemar G, Norlander B, Walan A (1977) Cimetidine in the treatment of active peptic ulcer disease. In: Burland WL, Alison Simkins M (eds) Proc of the 2nd Int Symp on histamine H2-receptor antagonists. Excepta Medica, Amsterdam Oxford, pp 224–239

    Google Scholar 

  4. Bourne HR, Lichtenstein LM, Melmon KL, Henney CS, Weistein Y, Shearer GM (1974) Modulation of inflammation and immunity by cyclic AMP. Science 184:19–28

    PubMed  Google Scholar 

  5. Clark RA, Sandler JA, Gallin JI, Kaplan AP (1977) Histamine modulation of eosinophil migration. J Immunol 118:137–145

    PubMed  Google Scholar 

  6. Dallegri F, Lanzi G, Patrone F (1980) Effects of ascorbic acid on neutrophil locomotion. Int Archs Allergy Appl Immun 61:40–45

    Google Scholar 

  7. Dankberg F, Persidsky MD (1976) A test of granulocyte membrane integrity and phagocytic function. Cryobiol 13:430–432

    PubMed  Google Scholar 

  8. De Cock W, De Cree J, Verhaegen H (1977) Restoration by levamisole of histamine-inhibited E rosette formation of T-lymphocytes of patients with allergies. Int Archs Allergy Appl Immun 54:176–182

    Google Scholar 

  9. De Cock W, De Cree J, Verhaegen H (1978) Histamine receptor bearing T-lymphocytes in patients with allergy, autoimmune disease, or recurrent infection. Clin Immunol Immunopathol 11:1–5

    PubMed  Google Scholar 

  10. Goetzl EJ (1978) Regulation of polymorphonuclear leukocytes chemotactic response by immunological reactions. In: Gallin JI, Quie PG (eds) Leukocyte chemotaxis: methods, physiology and clinical implications. Raven Press, New York, pp 161–174

    Google Scholar 

  11. Hill HR, Quie PG (1974) Raised serum-IgE levels and defective neutrophil chemotaxis in three children with eczema and recurrent bacterial infections. Lancet I:183–187

    Google Scholar 

  12. Ippoliti A, Peterson W (1979) The pharmacology of peptic ulcer disease. Clin Gastroenterol 8:53–67

    PubMed  Google Scholar 

  13. Keller HU, Wissler JH, Hess MW, Cottier H (1978) Distinct chemokinetic and chemotactic responses in neutrophil granulocytes. Eur J Immunol 8:1–7

    PubMed  Google Scholar 

  14. Lett-Brown MA, Leonard EJ (1977) Histamine-induced inhibition of normal human basophil chemotaxis to C5a. J Immunol 118:815–818

    PubMed  Google Scholar 

  15. Patrone F, Dallegri F, Brema F, Sacchetti C (1979) Effects of irradiation and storage on granulocytes harvested by continuous-flow centrifugation. Exp Hemat 7:131–136

    PubMed  Google Scholar 

  16. Plaut M, Lichtenstein LM, Henney CS (1975) Properties of a subpopulation of T cells bearing histamine receptors. J Clin Invest 55:856–874

    PubMed  Google Scholar 

  17. Richardson CT, Fordtran JS (1975) Effect of cimetidine, a new histamine H2-receptor antagonist in food stimulated secretion in duodenal ulcer patients. Gastroenterology 68:972

    Google Scholar 

  18. Russel RJ, Wilkinson PC, Sless F, Parrot DMV (1975) Chemotaxis of lymphoblasts. Nature 256:646–648

    PubMed  Google Scholar 

  19. Snyderman R, Rogers E, Buckley RH (1977) Abnormalities of leukotaxis in atopic dermatitis. J Allergy Clin Immunol 60:121–126

    PubMed  Google Scholar 

  20. Strannegard IL, Strannegard O (1977) Increased sensitivity of lymphocytes from atopic individuals to histamine-induced suppression. Scand J Immunol 6:1225–1231

    PubMed  Google Scholar 

  21. Verma SC, McNeill JH (1978) Histamine H2-receptor and the adenylate cyclase-cyclic AMP system. Can J Pharmacol Sci 13:1–3

    Google Scholar 

  22. Wang SR, Zweiman B (1978) Histamine suppression of human lymphocyte responses to mitogens. Cell Immunol 36:28–36

    PubMed  Google Scholar 

  23. Wilkinson PC (1974) Chemotaxis and inflammation. Churchill Livingstone, Edinburg London

    Google Scholar 

  24. Zigmond SH, Hirsch JG (1973) Leukocyte locomotion and chemotaxis. New method for evaluation and demonstration of a cell-derived chemotactic factor. J Exp Med 137:387–410

    PubMed  Google Scholar 

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Authors and Affiliations

  1. Second Medical Clinic, Department of Internal Medicine, University of Genova Medical School, I-16132, Genova, Italy

    Franco Patrone, Franco Dallegri, Gianfranco Lanzi & Carlo Sacchetti

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  1. Franco Patrone
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  2. Franco Dallegri
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  3. Gianfranco Lanzi
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  4. Carlo Sacchetti
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Patrone, F., Dallegri, F., Lanzi, G. et al. Reversal by cimetidine of histamine-induced inhibition of true chemotaxis in neutrophil polymorphonuclears. Res. Exp. Med. 176, 201–205 (1980). https://doi.org/10.1007/BF01855840

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  • DOI: https://doi.org/10.1007/BF01855840

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