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Somatostatin-gastrin interactions in the rat stomach

  • Original Papers
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Research in Experimental Medicine

Summary

Low concentrations of somatostatin and gastrin within or slightly above the range of physiologically circulating levels were perfused in the isolated, vascularly perfused rat stomach preparation. Somatostatin at 10 and 50 pg/ml significantly inhibited acetylcholine-stimulated gastrin secretion by 26% and 45%, respectively, whereas perfusion of 50 and 500 pg/ml exogenous gastrin did not modify gastric somatostatin secretion. Perfusion of somatostatin-antiserum significantly increased gastrin release by 235%. It is concluded that (1) somatostatin is a powerful inhibitor of the gastrin cell under in vitro conditions; the data are in accordance with a concept that endogenous somatostatin could act as a true hormone; (2) the secretory activity of the somatostatin cell is not significantly affected by circulating gastrin.

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Abbreviations

SLI:

somatostatin-like immunoreactivity

SRIF:

somatotropin releaseinhibiting hormone = somatostatin

SHG:

synthetic human gastrin

NRS:

normal rabbit serum

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Authors and Affiliations

  1. Division of Gastroenterology and Metabolism, Dept. of Medicine, Philipps University, Baldingerstr., D-3550, Marburg, Federal Republic of Germany

    H. Koop, E. Bothe, R. Eissele, J. Dionysius & R. Arnold

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  1. H. Koop
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  2. E. Bothe
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  3. R. Eissele
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  4. J. Dionysius
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  5. R. Arnold
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Koop, H., Bothe, E., Eissele, R. et al. Somatostatin-gastrin interactions in the rat stomach. Res. Exp. Med. 188, 115–121 (1988). https://doi.org/10.1007/BF01852267

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  • DOI: https://doi.org/10.1007/BF01852267

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