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Effects of forssman antibody on renal function of the guinea pig

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Research in Experimental Medicine

Summary

When guinea pigs were injected with rabbit anti-sheep red blood cell antiserum (Forssman antibody) by the intra arterial (i.a.) route (abdominal aorta at the level of the renal arteries), they developed renal disfunction. A diminished glomerular filtration rate associated with a 27% increase in the fractional excretion of K+ was observed. No alterations were noted in the fractional excretion of water and NA+.

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Author information

Authors and Affiliations

  1. Dept. of Parasitology, Microbiology, and Immunology, University of São Paulo, 14.049, Ribeirão Preto, SP-Brazil

    J. E. Barbosa

  2. Dept. of Internal Medicine, University of São Paulo, 14.049, Ribeirão Preto, SP-Brazil

    W. Sarti

  3. Dept. of Physiology Medical School of Ribeirão Preto, University of São Paulo, 14.049, Ribeirão Preto, SP-Brazil

    G. B. Mello

Authors
  1. J. E. Barbosa
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  2. W. Sarti
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  3. G. B. Mello
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Deceased

Supported in part by FAPESP grant no. 76/1178

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Barbosa, J.E., Sarti, W. & Mello, G.B. Effects of forssman antibody on renal function of the guinea pig. Res. Exp. Med. 187, 407–414 (1987). https://doi.org/10.1007/BF01852178

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  • DOI: https://doi.org/10.1007/BF01852178

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