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The presence of the S-100 protein in methylnitrosourea induced tumors of the nervous system in dogs

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Research in Experimental Medicine

Summary

The glia-specific protein S-100 has been demonstrated quantitatively in 1-methyl-1-nitrosourea-induced tumors of the dog CNS and PNS, which is a strong evidence for the neurooncogenic effect of MNU in the dog.

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References

  1. Benda, P., Someda, P. K., Messer, J., Sweet, W.: Morphological and immunological studies of rat glial tumors and clonal strains propagated in culture. J. Neurosurg.34, 310–323 (1971)

    PubMed  Google Scholar 

  2. Dannies, P.-S., Levine, L.: The role of sulfhydrals in the serological properties of the S-100 protein. J. biol. Chem.246, 6284 (1971)

    PubMed  Google Scholar 

  3. Druckrey, H., Ivankovic, S., Preussmann, R.: Selektive Erzeugung maligner Tumoren in Gehirn und Rückenmark von Ratten durch N-Methyl-N-nitrosoharnstoff. Z. Krebsforsch.66, 389–408 (1965)

    PubMed  Google Scholar 

  4. Haglid, K. G., Stavrou, D.: Water-soluble and pentanol-extractable proteins in human brain normal tissue and human brain tumors, with special reference to S-100 protein. J. Neurochem.20, 1523–1532 (1973)

    PubMed  Google Scholar 

  5. Moore, B. W.: A soluble protein characteristic of the nervous system. Biochem. biophys. Res. Commun.19, 739–744 (1965)

    PubMed  Google Scholar 

  6. Moore, B. W., Perez, V. J.: Complement fixation for antigens on a picogram level. J. Immunol.6, 1000–1005 (1966)

    Google Scholar 

  7. Rusca, G., Calissano, P.: Effect of Ca2+ on S-100 in long term incubation. Biochim. biophys. Acta (Amst.)221, 74–86 (1970)

    Google Scholar 

  8. Stavrou, D.: Zur vergleichenden Pathologie der Tumoren des Nervensystems. Zbl. Vet.-Med. A18, 585–645 (1971)

    Google Scholar 

  9. Stavrou, D., Haglid, K. G.: Experimentell induzierte Tumoren des peripheren Nervensystems beim Hund. Naturwissenschaften59, 317–318 (1972)

    PubMed  Google Scholar 

  10. Stavrou, D., Haglid, K. G.: Morphologische und immunologische Untersuchungen zur Histogenese experimenteller Hirntumoren. J. neurol. Sci.20, 39–50 (1973)

    PubMed  Google Scholar 

  11. Stavrou, D., Haglid, K. G., Rönnbäck, L.: The S-100 protein in rat brain and in methylnitrosourea-induced tumors of the rat nervous system. A quantitative study. Europ. Neurol.10, 168–178 (1973)

    PubMed  Google Scholar 

  12. Warzok, R., Schneider, J., Schreiber, D., Jänisch, W.: Experimental brain tumors in dogs. Experientia (Basel)26, 303–304 (1970)

    Google Scholar 

  13. Wechsler, W., Pfeiffer, S. E., Swenberg, J. A., Koestner, A.: S-100 protein in experimental rat tumors of the central and peripheral nervous system. Naturwissenschaften59, 370–371 (1972)

    PubMed  Google Scholar 

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Stavrou, D., Haglid, K.G. The presence of the S-100 protein in methylnitrosourea induced tumors of the nervous system in dogs. Res. Exp. Med. 164, 59–61 (1974). https://doi.org/10.1007/BF01851965

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  • DOI: https://doi.org/10.1007/BF01851965

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