Summary
Effects of the local infusion of bradykinin or isoproterenol were studied on the systemic blood pressure, blood flow, and vascular resistance of the submandibular gland before and after indomethacin treatment in cats. Both bradykinin and isoproterenol were shown to potently increase the glandular perfusion rate. The systemic arterial blood pressure fell by about 20% in response to indomethacin. The enhancement of blood flow by bradykinin or isoproterenol was not, however, affected by indomethacin treatment. The present results appear to suggest that the endogenous prostaglandins are not essentially involved in the development of responses produced by bradykinin or isoproterenol in the cat submandibular gland.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Bill A (1979) Effects of indomethacin on regional blood flow in conscious rabbits—a microsphere study. Acta Physiol Scand 105:437–442
Case RM, Conigrave AD, Novak I, Young JA (1980) Electrolyte and protein secretion by the perfused rabbit mandibular gland stimulated with acethyl-choline or catecholamines. J Physiol (Lond) 300:467–487
Corrado AP, Grellet M, Ribeiro RTN (1976) Possible mediation by endogenous prostaglandin of the sialagogic effect induced by bradykinin in dogs. Agents Actions 6:419
Fazekas Á, Pósch E, Zelles T (1983) Effect of indomethacin on blood flow of the rabbit submandibular gland. J Dent Res 62:537–539
Ferreira SH, Moncada S, Vane JR (1971) Indomethacin and aspirin abolish prostaglandin release from the spleen. Nature 231:237–239
Hierton C (1981) Effects of indomethacin, naproxen and paracetamol on regional blood flow in rabbits: a microsphere study. Acta Pharmacol Toxicol 49:327–333
Hilton SM, Lewis GP (1956) The relationship between glandular activity, bradykinin formation, and functional vasodilation in the submandibular salivary gland. J Physiol (Lond) 134:471–483
Messina EJ, Weiner R, Kaley G (1975) Inhibition of bradykinin vasodilation and potentiation of norepinephrine and angiotensin vasoconstriction by inhibitors of prostaglandin synthesis in skeletal muscle of the rat. Circ Res 37:430–437
Nowak J, Wennmalm A (1978) Influence of indomethacin and of prostaglandin E1 on total and regional blood flow in man. Acta Physiol Scand 102:484–491
Schachter M, Beilenson S (1968) Mediator of vasodilation in the submaxillary gland. Fed Proc 27:73–75
Terragno NA, Lonigro AJ, Malik KU, McGiff JC (1972) The relationship of the renal vasodilator action of bradykinin to the release of a prostaglandin E-like substance. Experientia 28:437–439
Terragno NA, Terragno DA, Pacholczyk D, McGiff JC (1974) Prostaglandins and the regulation of uterine blood flow in pregnancy. Nature 249:57–58
Vane JR (1971) Inhibition of prostaglandin synthesis as a mechanism of action for aspirinlike drugs. Nature 231:232–235
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Fazekas, A., Pósch, E. & Zelles, T. Effect of indomethacin on the bradykinin-induced vasodilation in the submandibular gland. Res. Exp. Med. 185, 319–323 (1985). https://doi.org/10.1007/BF01851957
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF01851957