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Effect of intracerebroventricular injection of prostaglandin E2 on anterior pituitary cell proliferation

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Research in Experimental Medicine

Summary

The influence of an intracerebroventricular (i.c.v.) injection of prostaglandin E2 (PGE2) on the mitotic activity of the rat anterior pituitary was investigated. It was found that i.c.v. PGE2 (3 µg/20 µl) resulted in a significant decrease of the mitotic activity in the anterior pituitary. This drop involved mainly chromophobic cells. No mitoses were found in acidophilic cells either in controls or in PGE2-treated rats. It is suggested that PGE2 may release an unidentified hypothalamic factor which inhibits the cell proliferation of the anterior pituitary.

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References

  1. Cardinali DP, Fernandez Pardal J, Gimeno MF, Gimeno AL (1982) Effects of estradiol on norepinephrine and prostaglandin efflux in medial basal hypothalamus of ovariectomized rats. J Neural Transm 53:39–47

    PubMed  Google Scholar 

  2. Eskay RL, Warberg J, Mical RS, Porter JC (1975) Prostaglandin E2-induced release of LHRH into hypophyseal portal blood. Endocrinology 97:816–825

    PubMed  Google Scholar 

  3. Herlant M, Pasteels JL (1967) Histophysiology of human anterior pituitary. Methods Achiev Exp Pathol 3:250–306

    Google Scholar 

  4. Lewiński A, Konopacki J, Pawlikowski M, Lewińska MK, Smith NKR, Reiter RJ (1984) Effect of intraventricular injections of 6-hydroxydopamine on anterior pituitary cell proliferation. Anat Rec 208:421–426

    PubMed  Google Scholar 

  5. Nouët JC, Kujas M (1975) Variations of mitotic activity in the adenohypophysis of male rats during a 24-hour cycle. Cell Tissue Res 164:193–200

    PubMed  Google Scholar 

  6. Ojeda SR, Campbell WB (1982) An increase in hypothalamic capacity to synthesize prostaglandin E2 precedes the first preovulatory surge of gonadotropins. Endocrinology 111:1031–1037

    PubMed  Google Scholar 

  7. Pawlikowski M (1981) Effect of prostaglandin synthesis inhibitors on the anterior pituitary cell proliferation. Endokrinologie 77:367–370

    PubMed  Google Scholar 

  8. Pawlikowski M, Kunert-Radek J, Lewiński A, Karasek E (1981) Indomethacin inhibits the estrogen-induced DNA synthesis in the rat anterior pituitary gland. Biochem Biophys Res Commun 101:1052–1056

    PubMed  Google Scholar 

  9. Pawlikowski M, Kunert-Radek J, Muszyńska B (1983) Estradiol enhanced prostaglandin E release from the medial basal hypothalamus but not from the anterior pituitary gland. Neuroendocrinol Lett 2:109–113

    Google Scholar 

  10. Paxinos G, Watson Ch (1982) The rat brain in stereotaxic coordinates. Academic Press, New York

    Google Scholar 

  11. Stępień H (1982) LH-RH inhibits [3H]-thymidine incorporation by pituitary cells cultured in vitro. Endocrinology 109:1784–1786

    Google Scholar 

  12. Zondek B (1936) Tumours of the pituitary induced with follicular hormone. Lancet 1:776–778

    Google Scholar 

Download references

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Authors and Affiliations

  1. Dept. of Experimental Endocrinology and Hormone Diagnostics, Institute of Endocrinology, Medical Academy of Łódź, 3, Dr. Sterling Street, PL 91-425, Łódź, Poland

    E. Sewerynek, A. Lewiński & M. Pawlikowski

  2. Dept. of Animal Physiology, Institute of Physiology and Cytology, University of Łódź, Łódź, Poland

    J. Konopacki & M. K. Lewińska

Authors
  1. E. Sewerynek
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  2. A. Lewiński
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  3. J. Konopacki
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  4. M. Pawlikowski
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  5. M. K. Lewińska
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Additional information

Supported by the Ministry of Health and Social Welfare of Poland (research project no. 10-RMZ-VII-1)

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Sewerynek, E., Lewiński, A., Konopacki, J. et al. Effect of intracerebroventricular injection of prostaglandin E2 on anterior pituitary cell proliferation. Res. Exp. Med. 186, 1–4 (1986). https://doi.org/10.1007/BF01851827

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  • DOI: https://doi.org/10.1007/BF01851827

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