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Einfluß von Katecholaminen und Sekretin auf die Serum-Gastrin-Konzentration beim Kaninchen

The influence of catecholamines and sekretin on the serum-gastrin-concentration in rabbits

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Research in Experimental Medicine

Summary

27 rabbits underwent infusion of epinephrine, norepinephrine and secretin. Gastrin concentration patterns were determined in serum before, during and after the infusion. There were no significant increases during epinephrine and norepinephrine infusion. During secretin and a combined secretin-epinephrine infusion there was a significant rise in serum gastrin concentration. The gastrin secretion pattern in rabbits influenced by catecholamines and secretin is in complete contrast to human conditions. That means that rabbits can only be used with a certain reserve in gastroenterological experiments.

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Literatur

  1. BRANDSBORG, O., BRANDSBORG, M., CHRISTENSEN, N.J.: Plasma adrenaline and serum gastrin: Studies in insulin induced hypoglycemia and after adrenaline infusions. Gastroenterology68, 455 (1975)

    PubMed  Google Scholar 

  2. HANSKY, J., CAIN, M.D.: Radioimmunoassay of gastrin in human serum. Lancet2, 1388 (1969)

    PubMed  Google Scholar 

  3. HANSKY, J., SOVENY, C., CAIN, M.: Immunoassay of gastrin in blood. Effect of secretin and histamine. Gastroenterology58, 958 (1970)

    Google Scholar 

  4. HANSKY, J., SOVENY, C., KORMAN, M.G.: Effect of secretin on serum gastrin as measured by immunoassay. Gastroenterology61, 62 (1971)

    PubMed  Google Scholar 

  5. HARJOLA, P.A., SIVULA, A.: Gastric ulcerations following experimentally induced hypoxia and hemorrhagic shock: In vivo study in pathogenesis in rabbits. Ann. Surg.163, 21 (1966)

    PubMed  Google Scholar 

  6. HAYES, J.R., ARDILL, J., KENNEDY, T.L., SHANKS, R.G., BUCHANAN, K.D.: Stimulation of gastrin release by catecholamines. Lancet1, 819 (1972)

    PubMed  Google Scholar 

  7. KONTUREK, S.J.: The effect of secretin on gastric acid secretion and peptic ulcers induced by pentagastrin in cats with intact or resected duodenum. Amer. J. Dig. Dis.13, 874 (1968)

    PubMed  Google Scholar 

  8. KRONBORG, O., PEDERSEN, T., STADIL, F., REHFELD, J.F.: The effect of betaadrenergic blockade upon gastric acid-secretion and gastrin secretion during hypoglycemia before and after vagotomy. Scand. J. Gastroenterol.9, 173 (1974)

    PubMed  Google Scholar 

  9. READ, R.C., THOMPSON, B.W., HALL, W.H.: Conversion of Hollander tests in man from positive to negative. Arch. Surg.104, 573 (1972)

    PubMed  Google Scholar 

  10. SKILLMANN, J.J., GOULD, S.A., CHUNG, R.S.: The gastric mucosal barrier: clinical and experimental studies in critically ill and normal man and in the rabbit. Ann. Surg.172, 564 (1970)

    PubMed  Google Scholar 

  11. STADIL, F., REHFELD, J.F.: Release of gastrin by epinephrine in man. Gastroenterology65, 210 (1973)

    PubMed  Google Scholar 

  12. STENING, G.F., JOHNSON, L.R., GROSSMAN, M.I.: Effect of secretin on acid and pepsin Secretion in cat and dog. Gastroenterology56, 468 (1969)

    PubMed  Google Scholar 

  13. THOMPSON, J.C., BUNCHMAN, H.H., REEDER, D.D.: Inhibition of gastrin release by secretin in man and in dogs. In: Gastrointestinal hormones. (Ed.: L. Demling), p. 86 Stuttgart: G. Thieme 1972

    Google Scholar 

  14. THOMPSON, J.C., REEDER, D.D., BUNCHMAN, H.H., BECKER, H.D., BRANDT, J.R., E.N.: Effect of secretin on circulating gastrin. Ann. Surg.176, 384 (1972)

    PubMed  Google Scholar 

  15. YALOW, R.S., BERSON, S.A.: Further studies on nature of immuno-reactive gastrin in human plasma. Gastroenterology60, 203 (1971)

    PubMed  Google Scholar 

  16. YALOW, R.S., BERSON, S.A.: Radioimmunoassay of gastrin. Gastroenterology58, 1 (1970)

    PubMed  Google Scholar 

  17. YALOW, R.S., BERSON, S.A.: Size and change distinctions between endogenous human plasma gastrin in peripheral blood and hepta-decapeptide gastrins. Gastroenterology58, 609 (1970)

    PubMed  Google Scholar 

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Schusdziarra, V., Müller-Wieland, K. Einfluß von Katecholaminen und Sekretin auf die Serum-Gastrin-Konzentration beim Kaninchen. Res. Exp. Med. 170, 203–210 (1977). https://doi.org/10.1007/BF01851391

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  • DOI: https://doi.org/10.1007/BF01851391

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