Summary
An open-chest dog heart model is presented which shows highly reproducible hemodynamic, electrophysiologic, and metabolic changes during and after short-term coronary occlusions. We repeatedly performed 3-min coronary ligations of the proximal ramus interventricularis anterior followed by reperfusion periods of 45 min. Thus, hemodynamic, metabolic, and electrophysiologic parameters of myocardial damage were fully reversible. The experimental model presented seems well suited to evaluate interventions which aim at influencing the extent and damage of myocardial ischemia without needing a large number of separate experiments.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Heyndrickx GR, Millard RW, McRitchie RJ, Maroko PR, Vatner SF (1975) Regional myocardial functional and electrophysiological alterations after brief coronary artery occlusion in conscious dogs. J Clin Invest 56:978–985
Maroko PR, Braunwald E, Covell JW, Ross J Jr (1969) Factors influencing the severity of myocardial ischemia following experimental coronary occlusion. Circulation [Suppl III] 39/40:140–148
Maroko PR, Kjekshus JK, Sobel BE, Watanabe T, Covell JW, Ross J Jr, Braunwald E (1971) Factors influencing infarct size following coronary artery occlusions. Circulation 43:67–82
Pagani M, Vatner SF, Bang H, Braunwald E (1978) Initial myocardial adjustements to brief periods of ischemia and reperfusion in the conscious dog. Circ Res 43:83–92
Sigmund-Duchanova H, Baller D, Bretschneider HJ, Prennschütz-Schützenau H, Piesker KH, Vennebusch H, Zipfel J, Hellige G (1979) Experimental validation of methods for the measurement of coronary sinus blood flow in man. Basic Res Cardiol 74:277–287
Weiner JM, Apstein CS, Arthur JH, Pirzada FA, Hood WB Jr (1976) Persistence of myocardial injury following brief periods of coronary occlusion. Cardiovasc Res 10:678–686
Wood JM, Hanley HG, Entman ML, Hartley CJ, Swain JA, Busch U, Chang CH, Lewis RM, Morgan WJ, Schwartz A (1979) Biochemical and morphological correlates of acute experimental myocardial ischemia in the dog. Circ Res 44:52–61
Author information
Authors and Affiliations
Additional information
Supported by the Deutsche Forschungsgemeinschaft, SFB 89, Kardiologie, Göttingen
Rights and permissions
About this article
Cite this article
Kahles, H., Mezger, V.A., Korb, H. et al. A new model for testing therapeutic interventions during myocardial ischemia. Res. Exp. Med. 182, 149–152 (1983). https://doi.org/10.1007/BF01851120
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF01851120