Abstract
The isolated heart–lung of the dog was introduced by Knowlton and Starling (1912). Since then, the dog model has been used for many physiological and pharmacological studies (Krayer 1931; Krayer and Mendez 1942; Somani and Blum 1966; Takeda et al. 1973; Ishikawa et al. 1978, 1983; Ono and O’Hara 1984; Ono et al. 1984; Caffrey et al. 1986; Hausknecht et al. 1986; Fessler et al. 1988; Seifen et al. 1987, 1988; Naka et al. 1989). More recently, the rat model has been preferred (Dietz 1984, 1987; Onwochei et al. 1987; Onwochei and Rapp 1988; Kashimoto et al. 1987, 1990, 1994, 1995; Fukuse et al. 1995).
References and Further Reading
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Gralinski, M., Neves, L.A.A., Tiniakova, O. (2014). Coronary Drugs. In: Hock, F. (eds) Drug Discovery and Evaluation: Pharmacological Assays. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-27728-3_5-1
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