Abstract
Fenbendazole (Panacur bolus, Hoechst India Ltd) was incorporated at a rate of 0.5 g/kg into urea-molasses blocks made by two different processes. The concentration of the drug in blocks and its bioavailability were measured using plasma oxfendazole as marker. The recovery of the drug in blocks made by a warm process was 68% and the plasma oxfendazole concentration remained fairly stable at 0.2 and 0.12 µg/ml from day 6 of feeding in cattle and buffalo, respectively. The drug seemed to be inactivated in blocks made by a hot process, with reduced bioavailability. A low and sustained plasma concentration of the active metabolite of the drug could be maintained by self-medication using urea-molasses blocks as fenbendazole carrier.
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Abbreviations
- FBZ:
-
fenbendazole
- HPLC:
-
high-performance liquid chromatography
- MUMB:
-
medicated urea-molasses blocks
- OFZ:
-
oxfendazole
- UMB:
-
urea-molasses block
References
Ali, D.N., Hennessy, D.R. and Murphy, L., 1990. Standard operating procedure for the extraction and quantification of fenbendazole from a molasses urea block.Annual Report (1.2.1989 to 31.1.1990). Self-Medication of Ruminants in Tethered Husbandry System. ACIAR Project 8523
Anderson, N. and Laby, R., 1977.Proceedings of World Association for Advancement of Veterinary Parasitology (Sydney), Abstract No. 4
Blagburn, B.L., Hanrahan, L.A., Hendrix, C.M. and Lindsay, D.S., 1987. Efficacy of fenbendazole-medicated blocks against gastrointestinal nematode infections in calves.American Journal of Veterinary Research,48, 1017–1019
Bogan, J.A. and Marriner, S.E., 1983. Uptake of fenbendazole by grazing sheep with access to feed blocks containing fenbendazole.British Veterinary Journal,139, 223–227
Campbell, W.C., 1990. Benzimidazole: veterinary uses.Parasitology Today,6, 130–133
Gottschall, D.W., Theodorides, V.J. and Wang, R., 1990. The metabolism of benzimidazole anthelmintics.Parasitology Today,6, 115–124
Hennessy, D.R., Lacey, E., Prichard, R.K. and Steel, J.W., 1985. Potentiation of the anthelmintic activity of oxfendazole by parbendazole.Journal of Veterinary Pharmacology and Therapeutics,8, 270–275
Prichard, R.K., Hennessy, D.R. and Steel, J.W., 1978. Prolonged administration: A new concept for increasing the spectrum and effectiveness of anthelmintics.Veterinary Parasitology,4, 309–315
Sanyal, P.K., 1993. Pharmacokinetic behaviour of fenbendazole in buffalo and cattle.Journal of Veterinary Pharmacology and Therapeutics, in press
Steel, R.L.D. and Torie, S.H., 1980.Principles and Procedures of Statistics, (McGraw-Hill, New York)
Zimmerman, G.L. and Hoberg, E.P., 1988. Controlled release devices for the delivery of anthelmintics in cattle.Parasitology Today,4, 55–56
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Sanyal, P.K., Singh, D.K. The uptake of fenbendazole by cattle and buffalo following long-term low-level administration in urea-molasses blocks. Vet Res Commun 17, 137–142 (1993). https://doi.org/10.1007/BF01839242
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DOI: https://doi.org/10.1007/BF01839242