Abstract
The purpose of this study was (1) to evaluate the technical and methodological problems associated with invasive haemodynamic measurements in unsedated cattle; (2) to assess the reproducibility of such measurements both within and between days; and (3) to compare the values with those previously reported.
Twenty-one healthy calves, aged from 5.5 to 12 months, were studied. The central venous, the right ventricular, the pulmonary arterial, the pulmonary capillary wedge and the systemic arterial pressures were obtained by means of fluid-filled catheters, and the cardiac output was measured by the thermodilution technique. The heart rate, the stroke volume, the pulmonary and systemic vascular resistances and the pulmonary and systemic ventricular workloads were calculated.
An adverse reaction, consisting of severe pulmonary hypertension, tachycardia, tachypnoea and transient weakness, occurred in 7 calves during the catheterization procedures. Such a reaction might be due to a local reflex induced by stimulation of mechano-receptors by the catheter tip. It should be avoided by reducing the manipulation of the catheter as much as possible and by inflating the tip of the balloon when moving it forwards. A comparison of the vascular pressures with those previously reported was difficult because of methodological or technical limitations, such as, for instance, a lack of standardization of the baseline. The reproducibility of the haemodynamic measurements obtained was satisfactory, in contrast to previous studies performed in conscious animals. This was attributed to our animals being better trained to the experimental conditions and emphasizes the importance of reducing mental stress in obtaining reliable haemodynamic measurements in unsedated and potentially uncooperative animals.
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References
Amory, H., Linden, A., Desmecht, D., Rollin, F., Genicot, B. and Lekeux, P., 1991. Validation of the thermodilution technique for the estimation of the cardiac output in the unsedated calves.Journal of Veterinary Medicine A,38, 409–417
Bergsten, G., 1974. Blood pressure, cardiac output and blood gas tension in the horse at rest and during exercise.Acta Veterinaria Scandinavica, Suppl 48, 1–88
Bisgard, G.E., Orr, J.A., Ungerer, T. and Will, J.A., 1972. Effect of training upon pulmonary and systemic hemodynamics in Beagle dogs.Laboratory for Animal Sciences,22, 72–76
Bisgard, G.E., Ruiz, A.V., Grover, R.E. and Will, J.A., 1973. Ventilatory control in the Hereford calf.Journal of Applied Physiology,35, 220–226
Blood, D.C., Radostits, O.M. and Henderson, J.A., 1985. Special examination of the cardiovascular system. In:Veterinary Medicine, 6th edn, (Baillière Tindall, Eastbourne), 278–283
Buss, D.D. and Bisgard, G.E., 1976. Myocardial function during acute hypoxia in the calf.Basic Research in Cardiology,71, 456–468
Darovic, G.O., 1987. In: D. Kay (ed.),Haemodynamic Monitoring. Invasive and Noninvasive Clinical Application, (W.B. Saunders, Philadelphia), 402 pp
Detweiler, D.K., 1984. The cardiovascular system and blood flow. In: M.J. Swenson (ed.),Duke's Physiology of Domestic Animals, 10th edn, (Cornell University Press), 69–87
Doyle, J.T., Patterson, J.L., Warren, J.V. and Detweiler, D.K., 1960. Observations on the circulation of domestic cattle.Circulation Research,8, 4–15
Franco, R.M., Ousey, J.C., Cash, R.S.G. and Rossdale, P.D., 1986. Study of arterial blood pressure in newborn foals using an electronic sphygmomanometer.Equine Veterinary Journal,18, 475–478
Greenlees, K.J., Gamble, R. and Eyre, P., 1986. Adrenoreceptor function in the bovine pulmonary circulation.Canadian Journal of Physiology and Pharmacology,64, 689–693
Gross, D.R., 1985. Normal cardiovascular parameters from intact, awake animals. In: Gross, D.R. (ed.),Animal Models in Cardiovascular Research, (Martinus Nijhoff, Dordrecht), 373–463
Gross, D.R., Dodd, K.T., Williams, J.D. and Adams, H.R., 1981. Adverse cardiovascular effects of oxytetracycline preparations and vehicles in intact, awake calves.American Journal of Veterinary Research,42, 1371–1377
Grover, R.F., Reeves, J.T., Will, D.H. and Blount, S.G., 1963. Pulmonary vasoconstriction in steers at high altitude.Journal of Applied Physiology,18, 567–574
Hall, L.W., 1984. Cardiovascular and pulmonary effects of recumbency in two conscious ponies.Equine Veterinary Journal,16, 89–92
Hall, L.W. and Nigam, J.M., 1975. Measurement of central venous pressure in horses.The Veterinary Record,97, 66–69
Holmberg, D.L. and Olsen, D.B., 1987. Anesthesia and cardiopulmonary bypass technique in calves and sheep.Veterinary Surgery,16, 463–465
Kohanna, F.H. and Cunningham, J.N., Jr, 1977. Monitoring of cardiac output by thermodilution after open-heart surgery.Journal of Thoracic Cardiovascular Surgery,73, 451–457
Kuhlmann, W.D., Hodgson, D.S. and Fedde, M.R., (1985). Respiratory, cardiovascular, and metabolic adjustments to exercise in the Hereford calf.Journal of Applied Physiology,58, 1273–1280
Kuida, H., Brown, A.M., Lange, R.L. and Hecht, H.H., 1961. Cardiovascular studies on normal calves.American Journal of Physiology,200, 247–252
Kuida, H., Brown, A.M., Thorne, J.L., Lange, R.L. and Hecht, H.H., 1962. Pulmonary vascular response to acute hypoxia in normal, unanesthetized calves.American Journal of Physiology,203, 391–396
McGuirk, S.M., Welker, F.H., Muir, W.W. and Hull, B.L., 1984. Thermodilution curves for diagnosis of ventricular septal defect in cattle.Journal of the American Veterinary Medical Association,184, 1141–1145
Mendenhall, W. and Reinmuth, J.E., 1978. The analysis of variance. In: Mendenhall, W. (ed.),Statistics of Management and Economics, 3rd edn, (Duxbury Press, North Scituate, MA), 465–502
Muylle, E., De Rosse, D., Oyaert, W. and Van Den Hende, C., 1975. Transposition of the aorta and atresia of the pulmonary trunk in a heifer.Journal of Veterinary Medicine A,22, 81–86
Nuytten, J., Muylle, E. and Oyaert, W., 1985. Pulmonary haemodynamics in healthy calves and in calves suffering from respiratory disorders.Zentralblatt für Veterinärmedizin A,32, 81–85
Olsen, J.D. and Booth, G.D., 1975. Normal values for aortic blood pressures and heart rates of cattle in a controlled environment.The Cornell Veterinarian,62, 85–100
Olsson, B., Pool, J., Vandermooten, P., Varnauskas, E. and Wassen, R., 1970. Validity and reproducibility of determination of cardiac output by thermodilution in man.Cardiology,55, 136–148
Parry, B.W., McCarthy, M.A. and Anderson, G.A., 1984. Survey of resting blood pressure values in clinically normal horses.Equine Veterinary Journal,16, 53–58
Peters, J.L., Hess, T.O., Leach, C.S., Imlay, T., Gardner, R.O., Donovan, F.M. and Van Kampen, K.R., 1973. Hemic and spirometric profiles in calves used for cardiovascular research.American Journal of Veterinary Research,34, 1595–1597
Reeves, J.T., Grover, R.F. and Will, D.H., 1962. Hemodynamics in normal cattle.Circulation Research,10, 166–171
Reeves, J.T. and Leathers, J.E., 1964. Circulatory changes following birth of the calf and the effect of hypoxia.Circulation Research,15, 343–354
Remillard, R.L., Ross, J.N. and Eddy, J.B., 1991. Variance of indirect blood pressure measurements and prevalence of hypertension in clinically normal dogs.American Journal of Veterinary Research,52, 561–565
Ruiz, A.V., Bisgard, G.E. and Will, J.A., 1973. Hemodynamic responses to hypoxia and hyperoxia in calves at sea level and altitude.Pfluegers Archiv,344, 275–286
Silove, E.D., Inoue, T. and Grover, R.F., 1968. Comparison of hypoxia, pH and sympathomimetic drugs on bovine pulmonary vasculature.Journal of Applied Physiology,24, 355–365
Sorensen, M.B., Bille Brahe, N.E. and Engell, H.C., 1975. Cardiac output measurement by thermal dilution: reproducibility and comparison with dye-dilution technique.Annals of Surgery,183, 67–72
Spörri, H., 1965. Studies of cardiac dynamics in animals (horses, cattle, sheep and goats).Annals of the New York Academy of Sciences,127, 379–392
Stenmark, K.R., Fasules, J., Hyde, D.M., Voelkel, N.F., Henson, J., Tucker, A., Wilson, H. and Reeves, J.T., 1987. Severe pulmonary hypertension and arterial adventitial changes in newborn calves at 4,300 m.Journal of Applied Physiology,62, 821–830
Wagner, A.E., Muir, W.W. and Grospitch, B.J., 1990. Cardiopulmonary effects of position in conscious cattle.American Journal of Veterinary Research,51, 7–10
Will, D.H., Horrell, J.F., Reeves, J.T. and Alexander, A.F., 1975. Influence of altitude and age on pulmonary arterial pressure in cattle.Proceedings of the Society for Experimental Biology and Medicine,150, 564–567
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Amory, H., Linden, A.S., Desmecht, D.J.M. et al. Technical and methodological requirements for reliable haemodynamic measurements in the unsedated calf. Vet Res Commun 16, 391–401 (1992). https://doi.org/10.1007/BF01839188
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DOI: https://doi.org/10.1007/BF01839188