Summary
DTPA-Sn-99 mTc is an excellent radionuclide for brain scintigraphy procedures with a rapid blood clearance through glomerular filatration. No previous preparation of the patient is necessary. We have studied forty nine patients with primary or metastatic brain tumours as well as calvarium metastases. There have been five false negatives. We have found three types of scintigraphic patterns depending on whether the lesion is better visualized in early or late images, or does not change throughout the study. The sequential brain study, obtaining views at five minutes, and at one and two hours post-injection allows for an adequate morphological characterization of the lesion and occasionally, a histological diagnosis.
Similar content being viewed by others
References
Hauser, W., Atkins, H. L., Nelson, K. G., Technetium-99 mTc-DTPA: A new radiopharmaceutical for brain and kidney scanning. Radiol.94 (1970), 679–684.
Konikowski, T., Jahns, M. F., Haynie, T. P., Glenn, H. J., Brain tumorscanning agents compared in an animal model. J. Nucl. Med.16, 3 (1975), 200–207.
O'Mara, R. E., Mozley, J. M., Current status of brain scanning. Seminars in Nuclear MedicineI, 1 (1970), 7–31.
Witcofski, R. L., Maynard, C. D., Roper, T. S., A comparative analysis of the accuracy of the technetium-99 m pertechnetate brain scan: Follow-up of 1,000 patients. J. Nucl. Med.8 (1967), 187.
Burrows, E. H., False negative results in brain scanning. Brit. Med. J.I (1972), 473–476.
Conway, J. J., Quinn III, J. L., Brain imaging in pediatrics. Pediatrie Nuclear Medicine, pp. 115–126. Saunders. 1974.
Mahin, D., Wagner, H. N., Jr., The value of brain scans in pediatrics. Pediatric Nuclear Medicine, pp. 103–115. Saunders. 1974.
Mishkin, F. S., Central nervous system: Brain. Nuclear Medicine in clinical pediatrics, pp. 7–22. Hirsch Handmaker. 1975.
Gilday, D. L., Eng, B., Ash, J., Accuracy of brain scanning in pediatric craniocerebral neoplasms. Radiol.117 (1975), 93–97.
Burrows, E. H., The clinical utility of brain scanning in Nuclear Medicine. Progress in Nuclear Medicine: Neuro Nuclear Medicine, pp. 287–335. S. Karger. 1972.
Lee, M. J., A study on the diagnosis of brain tumors with radioactive isotopes (Koream). Korea Univ. Med. J.10, 1 (1973), 45–60.
Moody, R. A., Olsen, J. O., Gottschalk, A., Hoffer, P. B., Brain scans of the posterior fossa. J. Neurosurg.36 (1972), 148–152.
Baun, S., Rothballer, A. B., Shiffman, F., Girolamo, R. F., Brain scanning in the diagnosis of acoustic neuromas. J. Neurosurg.36 (1972), 141–147.
Burrows, E. H., Rad, M., Scintigraphic diagnosis of acoustic neurofibromas. Brit. J. Radiol.48 (1975), 1000–1006.
Lomas, F., Use of the pinhole collimator in pediatrics. Pediatrie Nuclear Medicine, pp. 72–78. Saunders. 1974.
Heck, L., Gottschald, A., Use of the pinhole collimator for imaging the posterior fossa in brain scans. Radiol.101 (1971), 443–444.
Holmes, R. A., The vertex view in routine brain scanning. Amer. J. Roentgenol.106 (1969), 347–353.
Holmes, R. A., Value of the vertex view in brain scanning. Seminars in Nuclear MedicineI, 1 (1970), 48–55.
James, A. E., DeLand, F. H., Hodges, F. J., Wagner, H. N., Jr., Radionuclide imaging in the detection and differential diagnosis of craniopharyngiomas. Amer. J. Roentgenol.109, 4 (1970), 692–700.
Leonard, J. R., Witherspoon, L. R., Mahaley, M. S., Jr., Goodrich, J. K., Value of sequential postoperative brain scans in patients with anaplastic gliomas. J. Neurosurg.42 (1976), 551–556.
Clark, E. E., Hattner, R. S., Brain scintigraphy in recurrent medulloblastoma. Radiology119 (1976), 633–636.
Calogero, J., Crafts, D. C., Wilson, C. B., Bildrey, E. B., Rosenberg, A., Enot, K. J., Long-term survival for patients treated with BCNU for brain tumors. J. Neurosurg.43 (1975), 191–196.
Flipse, R. C., Vuksanovic, M., Fonts, E. A., Sequential brain scanning in radiation therapy of malignant tumors of the brain. Amer. J. Roentgenol.102 (1968), 93–96.
Kieffer, S. A., Loken, M. K., Positive “brain” scans in fibrous dysplasia and other lesions of the skull. Amer. J. Roentgenol.106, 4 (1969), 731–738.
Wolfosteiu, R. S., Tanasescu, D., Sakimura, I. T., Waxman, A. D., Siemsen, J. K., Brain imaging with 99 mTc-DTPA: A clinical comparison of early and delayed studies. J. Nucl. Med.15, 12 (1974), 1135–1137.
Brstein, J., Hoffer, P. B., Use of delayed brain scan in differentiating calvarial from cerebral lesions. J. Nucl. Med.15, 8 (1974), 681–684.
Rockett, J. F., Kaplan, E. S., Ray, M., Buchignani, J. S., Gardner, H. C., Scintiphotographic demonstration of bilateral infarction in the distribution of the anterior cerebral arteries. Radiol.112 (1974), 125–137.
DeLand, F. H., Scanning in cerebral vascular disease. Seminars in Nuclear MedicineI, 1 (1971), 31–40.
Hahn, F. J., Rice, A. C., Christie, J. H., Occlusion of posterior cerebral artery: Scintiscan and angiographic findings. Radiol.112 (1974), 131–133.
Reba, R. C., Poulose, K. P., Nonspecificity of gallium accumulation: Gallium-67 concentration in cerebral infarction. Radiol.112 (1974), 639–641.
Wallner, R. J., Croll, M. N., Brady, L. W., 67-Ga localization in acute cerebral infarction. J. Nucl. Med.15, 4 (1974), 308–309.
Waxman, A. D., Siemsen, J. K., Lee, G. C., Wolfstein, R. S., Moser, L., Reliability of gallium brain scanning in the detection and differentiation of central nervous system lesions. Radiol.116 (1975), 675–678.
Henkin, R. E., Quinn III, J. L., Weinberg, P. E., Adjunctive brain scanning with Ga-67 in metastasis. Radiol.106 (1973), 595–599.
Jones, A. E., Frankel, R. S., DiChiro, G., Johnston, G. S., Brain scintigraphy with 99 mTc pertechnetate, 99 mTc polyphosphate, and 67-Ga citrate. Radiol.112 (1974), 123–129.
Grames, G. M., Jansen, C., Carlsen, E. N., Davidson, T. R., The abnormal bone scan in intracranial lesions. Radiol.115 (1975), 129–134.
Wenzel, W. W., Heasty, R. G., Uptake of 99 mTc-stannous polyphosphate in an area of cerebral infarction. J. Nucl. Med.15, 3 (1974), 207–209.
Zülch, K. J., Brain tumors: their biology and pathology. New York: Springer. 1965.
Gottschalk, A., Abatie, J. D., Petasnick, J. P., Polcyn, R. E., Beck, R. N., Charleston, D. B., Comparison between sensitivity and resolution based on clinical evaluation with ACRH brain scanner. Symposium on Medical Radioisotope Scintigraphy, Salzburg, Austria. 1968.
Tarcan, Y. A., Fajman, W., Marc, J., Berg, D., “Doughnout” sign in brain scanning. Amer. J. Roentgenol.126, 4 (1976), 842–852.
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Calatayud-Maldonado, V., Banzo-Marraco, J., Uriguen-Saiz, M. et al. Diagnosis of intracranial space-occupying lesions With DTPA-Sn-99mTc. Acta neurochir 41, 301–310 (1978). https://doi.org/10.1007/BF01811343
Issue Date:
DOI: https://doi.org/10.1007/BF01811343