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Aminoglutethimide treatment in advanced breast cancer: An efficient therapy as a late endocrine alternative in a sequential therapeutic approach

  • Scandinavian Breast Cancer Symposium
  • Published:
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Summary

During the last 2 years we have treated 24 patients (23 females and 1 male) with aminoglutethimide plus glucocorticoid for advanced breast cancer. More than half of the patients had received more than 3 systemic treatments before start of aminoglutethimide (AG), and at least half of the patients had been given more than 2 different endocrine regimens. There were 8 previous responders to endocrine therapy and in 10 patients steroid receptor status predicted response to therapy.

Nine of 22 patients (two had to stop after less than 1 month due to acute toxicity) had an objective response; there were 2 complete responders. Most side effects were not serious, subsiding within a few weeks. In one patient agranulocytosis was observed. AG with glucocorticoid replacement seems to be an effective treatment as a late endocrine alternative in a sequence of different endocrine regimens.

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Authors and Affiliations

  1. Department of Oncology, Haukeland Hospital, University of Bergen, Bergen, Norway

    Stener Kvinnsland M.D. & Olav Dahl M.D.

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  1. Stener Kvinnsland M.D.
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  2. Olav Dahl M.D.
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Kvinnsland, S., Dahl, O. Aminoglutethimide treatment in advanced breast cancer: An efficient therapy as a late endocrine alternative in a sequential therapeutic approach. Breast Cancer Res Tr 3, 73–76 (1983). https://doi.org/10.1007/BF01806236

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  • DOI: https://doi.org/10.1007/BF01806236

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