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Regulatory functions of protein kinase c in glomerular mesangial cells

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Summary

Protein kinase C is a family of isozymes that are activated by hormone-stimulated phosphoinositide hydrolysis and participate in the signalling process by phosphorylating certain target proteins. In glomerular mesangial cells protein kinase C fulfills two major functions: it contributes to hormone-induced prostaglandin formation, and it acts as a negative feedback regulator of the inositol lipid signalling cascade. Furthermore, protein kinase C activates a phosphatidylcholine-degrading phospholipase D activity with as-yet-unknown cellular function.

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Abbreviations

PKC:

protein kinase C

PLA2 :

phospholipase A2

PLC:

phospholipase C

PLD:

phospholipase D

IP3 :

inositol 1,4,5-trisphosphate

DAG:

1,2-diacylglycerol

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Authors and Affiliations

  1. Research Department, Pharmaceuticals Division, Ciba-Geigy Ltd., Basel, Switzerland

    J. Pfeilschifter

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  1. J. Pfeilschifter
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Pfeilschifter, J. Regulatory functions of protein kinase c in glomerular mesangial cells. Klin Wochenschr 68, 1134–1137 (1990). https://doi.org/10.1007/BF01798064

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