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Orthologous nature of mammaliam insulin genes

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Summary

Investigation of 7 insulin sequences from a bony fish, a bird, and 5 mammalian species showed that guinea pig and coypu insulin, that have a strongly divergent primary and quarternary structure, are not the result of gene duplication in an ancient vertebrate or invertebrate ancestor but that they diverged from the other mammals after divergence of the mammals from the other vertebrates. After this divergence both insulins underwent evolution at a highly increased rate.

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References

  • Blundell, T.L., Wood, S.P. (1975). Nature257, 197–203

    Google Scholar 

  • Brown, H., Sanger, F., Kitai, R. (1955). Biochem. J.60, 556–565

    Google Scholar 

  • Dayhoff, M.O. (1972). Atlas of protein sequence and structure, vol. 5 pp. D-176, D-186 and Suppl. I (1973) p. S-53. Washington: National Biomedical Research Foundation

    Google Scholar 

  • Fitch, W.M. (1971). Syst. Zool.20, 406–416

    Google Scholar 

  • Fitch, W.M. (1973). Ann. Rev. Genet.7, 343–381

    Google Scholar 

  • Fitch, W.M. (1975). Proceedings of Eight International Congress on Numerical Taxonomy, G.F. Estabrook, ed., pp. 189–230. San Francisco: Freeman

    Google Scholar 

  • Fitch, W.M., Farris, J.S. (1974). J. Mol. Evol.3, 263–278

    Google Scholar 

  • Goodman, M., Moore, G.W., Barnabas, J. (1974). J. Mol. Evol.3, 1–48

    Google Scholar 

  • Mann, G.V., Crofford, O.B. (1970). Science169, 1312–1313

    Google Scholar 

  • Massey, D.E., Smyth, D.G. (1975). J. Biol. Chem.250, 6288–6290

    Google Scholar 

  • Morris, D. (1965). The Mammals. London: Hodder and Stoughton

    Google Scholar 

  • Neville, R.W.J., Weir, B.J., Lazarus, N.R. (1974). Symp. Zool. Soc. London34, 417–435

    Google Scholar 

  • Raulais, D., Hagaman, J., Ontjes, D.A., Lundblad, R.L., Kingdon, H.S. (1976). Eur. J. Biochem.64, 607–611

    Google Scholar 

  • Reid, K.B.M., Grant, P.T., Youngson, A. (1968). Biochem. J.110, 289–296

    Google Scholar 

  • Smith, L.F. (1966). Am. J. Med.40, 662–666

    Google Scholar 

  • Smith, L.F. (1972). Diabetes,21 (Suppl. 2), 457–460

    Google Scholar 

  • Wood, S.P., Blundell, T.L., Wollmer, A., Lazarus, N.R., Neville, R.W.J. (1975). Eur. J. Biochem.55, 531–542

    Google Scholar 

Download references

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Authors and Affiliations

  1. Biochemisch Laboratorium, Rijksuniversiteit, Groningen, The Netherlands

    Jaap J. Beintema

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  1. Jaap J. Beintema
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Beintema, J.J. Orthologous nature of mammaliam insulin genes. J Mol Evol 9, 363–366 (1977). https://doi.org/10.1007/BF01796099

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  • DOI: https://doi.org/10.1007/BF01796099

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