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Evidence for arsenic essentiality

Environmental Geochemistry and Health volume 14, pages 55–58 (1992)Cite this article

Abstract

Although numerous studies with rats, hamsters, minipigs, goats and chicks have indicated that arsenic is an essential nutrient, the physiological role of arsenic is open to conjecture. Recent studies have suggested that arsenic has a physiological role that affects the formation of various metabolites of methionine metabolism including taurine and the polyamines. The concentration of plasma taurine is decreased in arsenic-deprived rats and hamsters. The hepatic concentration of polyamines and the specific activity of an enzyme necessary for the synthesis of spermidine and spermine, S-adenosylmethionine decarboxylase, are also decreased in arsenic-deprived rats. Thus, evidence has been obtained which indicates that arsenic is of physiological importance, especially when methionine metabolism is stressed (e.g. pregnancy, lactation, methionine deficiency, vitamin B6 deprivation). Any possible nutritional requirement by humans can be estimated only by using data from animal studies. The arsenic requirement for growing chicks and rats has been suggested to be near 25 ng g−1 diet. Thus, a possible human requirement is 12 μg day−1. The reported arsenic content of diets from various parts of the world indicates that the average intake of arsenic is in the range of 12–40 μg. Fish, grain and cereal products contribute most arsenic to the diet.

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References

  • Anke, M. 1986. Arsenic. In: Mertz, W. (ed.),Trace Elements in Human and Animal Nutrition, pp. 347–372. Academic Press, Orlando.

    Google Scholar 

  • Anke, M., Grün, M. and Partschefeld, M. 1976. The essentiality of arsenic for animals. In: Hemphill, D.D. (ed.),Trace Substances in Environmental Health, pp. 403–409. University of Missouri, Columbia.

    Google Scholar 

  • Benko, V. 1987. Arsenic. In: Fishbein, L., Furst, A. and Mehlman, M.A. (eds.),Genotoxic and Carcinogenic Metals: Environmental and Occupational Occurrence and Exposure, pp. 1–30. Princeton Scientific, Princeton.

    Google Scholar 

  • Comatzer, W.E., Uthus, E.O., Haning, J.A. and Nielsen, F.H. 1983. Effect of arsenic deprivation on phosphatidylcholine biosynthesis on liver microsomes in the rat.Nutr. Reports Int.,27, 821–829.

    Google Scholar 

  • Desrosiers, R. and Tanguay, R.M. 1986. Further characterization of the posttranslational modifications of core histones in response to heat and arsenite stress inDroscphilia.Biochem. Cell. Biol.,64, 750–757.

    Google Scholar 

  • Jänne, J., Hölttä, E., Kallio, A. and Käpyaho, K. 1983. Role of polyamines and their antimetabolites in clinical medicine.Spec. Top. Endocrinol. Metab.,5, 227–293.

    Google Scholar 

  • Nielsen, F.H. 1988. The ultratrac: elements. In: Smith, K.T. (ed.),Trace Minerals in Foods, pp. 357–428. Marcel Dekker, New York.

    Google Scholar 

  • Nielsen, F.H. 1990. Other trace elements. In: Brown, M.L. (ed.).Present Knowledge in Nutrition, pp. 294–307. International Life Sciences Institute, Washington, DC.

    Google Scholar 

  • Nielsen, F.H., Givand, S.H. and Myron, D.R. 1975. Evidence of a possible requirement for arsenic by the rat.Fed. Proc., Fed. Am. Soc. Exp. Biol.,34, 923 (Abstract).

    Google Scholar 

  • Nielsen, F.H. and Shuler, T.R. 1978. Arsenic deprivation studies in chicks.Fed. Proc., Fed. Am. Soc. Exp. Biol.,37, 893, (Abstract).

    Google Scholar 

  • Rapaport, S.I. 1971.In: Introduction to Hematology, pp. 133–135. Harper and Row, New York.

    Google Scholar 

  • Uthus, E.O. 1990. Effects of arsenic deprivation in hamsters.Magnesium Trace Elem.,9, 227–232.

    Google Scholar 

  • Uthus, E.O. and Nielsen, F.H. 1956. Effects of dietary guanidoacetic acid on arsenic deprivation in chicks.N.D.Acad. Sci.,40, 84.

    Google Scholar 

  • Uthus, E.O. and Nielsen, F.H. 1987. Methyl depletion affects the response of rats to arsenic deprivation.Nutr. Res.,7, 1061–1072.

    Google Scholar 

  • Uthus, E.O. and Poellot, R. 1991. The effect of dietary pyridoxine on arsenic deprivation in rats.FASEB J.,5, A1312 (Abstract).

    Google Scholar 

  • Uthus, E.O., Poellot, R. and Nielsen, F.H. 1989. The effect of arsenic deprivation on polyamine content and the activity of S-adenosylmethionine and omithine decarboxylase in rat liver. In: Anke, M., Baumann, W., Bräunlich, H., Bruckner, C., Groppel, B. and Grün, M. (eds.),Sixth International Trace Element Symposium 1989. PP. 1013–1017. Jena.

  • Vahter, M. and Marafante, E. 1988. In vivo melhyiation and detoxication of arsenic.Spec. Publ. Roy. Soc. Chem.,66, 105–119.

    Google Scholar 

  • van Bergenen, Henegouwen, P.M.P. and Linnemans, W.A.M. 1987. Heat shock gene expression and cytoskeletal alterations in mouse neuroblastoma cells.Exp. Cell Res.,171, 367–375.

    Google Scholar 

  • Zelikovic, I. and Chesney, R.W. 1989. Taurine. In: Spiller, G.A. and Scala, J. (eds.),New Protective Roles for Selected Nutrients, pp. 253–294. Alan R. Liss, New York.

    Google Scholar 

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Authors and Affiliations

  1. United States Department of Agriculture, Agricultural Research Service, Grand Forks Human Nutrition Research Center, University Station, PO Box 7166, 58202-7166, Grand Forks, ND, USA

    Eric O. Uthus

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  1. Eric O. Uthus
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Uthus, E.O. Evidence for arsenic essentiality. Environ Geochem Health 14, 55–58 (1992). https://doi.org/10.1007/BF01783629

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  • DOI: https://doi.org/10.1007/BF01783629

Keywords

  • Enzyme
  • Arsenic
  • Geochemistry
  • Methionine
  • Taurine