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Imbalanzen neutraler Plasma-Aminosäuren als pathogenetischer Faktor der Anorexie

Imbalances of neutral plasma amino acids as pathogenetic factor of anorexia

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Summary

Studies in anorectic tumor-bearing rats indicate that anorexia is correlated to imbalances of neutral amino acids in blood and CNS. Consequently plasma amino acids of patients with neoplastic and non-neoplastic internal diseases were studied during phases of anorexia; special regard was given to the precursors of dopamine and serotonin. Anorectic patients were compared to non-anorectic patients with neoplasia. During anorexia, plasma levels of valine and leucine and hence the ratio of the molar concentrations of Val+Leu+Ile/Phe+Tyr were significantly decreased in each anorectic patient as compared to non-anorectic patients whose ratios were always within the normal ranges. As aromatic and branched-chain amino acids compete for penetration of the blood brain barrier, the decrease of the amino acid ratio may induce a raised flux of phenylalanine and tyrosine into the CNS which results in an increased activation of dopaminergic neurons — known to cause anorexia.

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Abbreviations

AS:

Aminosäuren

CML:

Chronisch-myeloische Leukämie

Ile:

Isoleucin

Leu:

Leucin

m:

männlich

M:

Median

Phe:

Phenylalanin

Tyr:

Tyrosin

Val:

Valin

VZK:

Verzweigtkettige Aminosäuren

w:

weiblich

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Authors and Affiliations

  1. Medizinische Klinik II der Universität Köln, Germany

    G. Ollenschläger & R. Lang

  2. Forschungsinstitut für experimentelle Ernährung e.V., Erlangen

    W. Fekl

  3. Abteilung für Klinische Chemie, Universitätskliniken Köln, Germany

    J. Schindler

Authors
  1. G. Ollenschläger
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  2. R. Lang
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  3. W. Fekl
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  4. J. Schindler
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Herrn Prof. Dr. W. Kaufmann zur Vollendung des 60. Lebensjahres gewidmet

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Ollenschläger, G., Lang, R., Fekl, W. et al. Imbalanzen neutraler Plasma-Aminosäuren als pathogenetischer Faktor der Anorexie. Klin Wochenschr 62, 1102–1107 (1984). https://doi.org/10.1007/BF01782466

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  • DOI: https://doi.org/10.1007/BF01782466

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