Summary
A decrease of cardiac output during artificial ventilation with PEEP has been reported in 30–100% of patients. The drop in cardiac output is caused by (I) a decrease of transmural filling pressures of both ventricles, (II) an increase in afterload of the right ventricle, (III) a change of left ventricular geometry caused by a right to left shift of the interventricular septum in face of an enlargeing right ventricle. Afterload enhancement and right to left interdependance are effective on high PEEP levels only (above 15 cm H2O). Pulmonary occlusion pressure represents left ventricular filling pressure up to PEEP 10–15 cm H2O. A rise of cardiac output during PEEP may be seen (I) in patients with severe left ventricular failure, where hemodynamics may ameliorate with PEEP (II) in patients with very stiff lungs and low FRC before ventilation. A drop in mean arterial blood pressure was observed in a certain number of patients, while arterial pressure remained constant in others. PEEP should not be delivered to patients with arterial hypotension and hypovolimia before stabilisation of circulation and volume replacement. Regional blood flow is significantly altered during PEEP. In dog experiments a redistribution of peripheral blood flow was observed favouring the flow to brain, heart, adrenal glands small intestine and sceletal muscle and ischemia of stomach, thyroideal and fatty tissue blood flow. Within the kidney, a redistribution of blood flow away from the outer cortex compromises the kidney function (decrease of glomerula filtration, urine output and sodium excretion). Intracranial pressure increases during PEEP, and cerebral perfusion pressure defined as arterial minus intracranial resp. central venous pressure decreases, which is of clinical importance in patients with compromised autoregulation of cerebral blood flow. Hemodynamic side effects of positive pressure ventilation may be compensated for by means of volume expansion, dopamine or dobutamine infusion, and use of alternative respiratory support (IMV, CPAP). The concept of best PEEP has to be reassesed on the basis of recent knowledge in pathophysiology and respiratory therapy.
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Literatur
Aidinis SJ, Lafferty J, Shapiro HM (1976) Intracranial responses to PEEP. Anesthesiology 45:275–286
Anat G, Viale JP, Bui Xuan B, Aissa H, Benzoni D, Vincent M, Gharib C (1983) Effect of PEEP ventilation on renal function, plasma renin, aldosterone, neurophysins and urinary ADH, and prostaglandins. Anesthesiology 58:136–141
Augustin HJ, Bischoff K, Engels Th (1979) Der Einfluß von Dopamin auf die Nierenfunktion während kontinuierlicher Überdruckbeatmung (PEEP). Anaesthesist 28:159–162
Baratz RA, Philbin DM, Patterson RW (1971) Plasma antidiuretic hormone und urinary output during continuous positive pressure breathing in dogs. Anesthesiology 34:510–513
Benzer H, Haider W, Kundi M, Laczkovics A, Todt W (1977) Die Kombination von kontinuierlicher Überdruckbeatmung (PEEP) und Dopamin beim postkardiochirurgischen Patienten. Herz 2:465–472
Beyer J, Conzen P, Schosser R, Messmer K (1980) The effect of PEEP ventilation on hemodynamics and regional blood flow with special regard to coronary blood flow. Thorac Cardiovasc Surg 28:128–132
Beyer J, Meßmer K (1982) Organdurchblutung und Sauerstoffversorgung bei PEEP. Springer, Berlin Heidelberg New York
Bonnet F, Richard C, Glaser P, Lafay M, Gnesde R (1982) Changes in hepatic flow induced by continuous positive pressure ventilation in critically ill patients. Crit Care Med 10:703–705
Brandl M, Pasch T, Kamp HD, Grimm J (1983) Comparison of the effects of Dopamine and Dobutamine during continuous positive-pressure ventilation. Intens Care Med 9:61–67
Cassidy SS, Robertson CH, Pierce AK, Johnson RL (1978) Cardiovascular effects of positive end-expiratory pressure in dogs. J Appl Physiol 44:743–750
Chapin JC, Downs JB, Douglas ME, Murphy EJ, Ruiz BC (1979) Lung expansion, airway pressure transmission, and positive end-expiratory pressure. Arch Surg 114:1193–1197
Cournand A, Motley HL, Werko L, Richards DW (1948) Physiological studies of the effects of intermittent positive pressure breathing on cardiac output in man. Am J Physiol 152:162–173
Cyran J, Hellwig H, Bolte HD, Karabensch JF, Scherpe A, v Gosen J, Krüger R, Lüderitz B (1978) Zum Dosierungsproblem der Nitroglyzerindauerinfusion bei Patienten mit schwerer Herzinsuffizienz. Intensivmed 15:156–160
Dhainaut JF, Bricard C, Monsallier FJ, Salmon O, Bons J, Fourestie V, Schlemmer B, Carli A (1982) Crit Care Med 10:631–635
Dhainant JF, Devaux JY, Schlemmer B, Salmon O, Fourestie V, Carli A, Monsallier JF (1983) Effects of PEEP on right ventricular function in ARDS patients (Abstract). Intens Care Med 9:149
Dudziak R, Satter P, Forster K (1967) Die Auswirkung der Beatmung mit einem volumen- und einem druckgesteuerten Respirator auf den Kreislauf und den Gasaustausch. In: Just OH, Stoeckel H (Hrsg) Die Ateminsuffizienz und ihre klinische Behandlung. Thieme, Stuttgart, S 78–82
Ellmann H, Dembin H (1982) Lack of adverse hemodynamic effects of PEEP in patients with acute respiratory failure. Crit Care Med 10:706
Falke KJ, Pontoppidan H, Kumar A, Leith DE, Geffin B, Laver MB (1972) Ventilation with end-expiratory pressure in acute lung disease. J Clin Invest 51:2315–2323
Gallagher TJ, Civetta JM, Kirby RR (1978) Terminology up date: optimal PEEP. Crit Care Med 6:323
Grace MP, Greenbaum DM (1979) Effect of positive end-expiratory pressure on cardiac performance in patients with cardiac dysfunction. Crit Care Med 7:143
Hall SV, Johnson EE, Hedley-Whyte J (1974) Renal hemodynamics and function with continuous positive-pressure ventilation in dogs. Anesthesiol 41:452–461
Hemmer M, Suter PM (1979) Treatment of cardiac and renal effects of PEEP with Dopamine in patients with acute respiratory failure. Anesthesiol 50:399–403
Jardin F, Farcot JC, Boisante L, Curien N, Margairaz A, Bourdarias JP (1981) Influence of positive end-expiratory pressure on left ventricular performance. N Engl J Med 304:387–392
Kirby RR, Downs JB, Civetta JM, Modell JH, Dannemiller FJ, Klein EF, Hodges M (1975) High level positive end-expiratory pressure (PEEP) in acute respiratory insufficiency. Chest 67:156–163
Kumar A, Pontoppidan H, Baratz RA, Laver MB (1974) Inappropriate response to increased plasma ADH during mechanical ventilation in acute respiratory failure. Anesthesiol 40:215–221
Laver MB, Strauss HW, Pohost GM (1979) Right and left ventricular geometry: adjustments during acute respiratory failure. Crit Care Med 7:509–519
Lozman J, Powers SR, Older T, Dutton RE, Roy RJ, English M, Marco D, Eckert C (1974) Correlation of pulmonary wedge and left atrial pressures. Arch Surg 109:270–276
Luckmann E, Heinz N, Hossmann V (1973) Künstliche Beatmung bei akuter schwerer Linksherzinsuffizienz. Intensivmed 10:276–281
Lutch JS, Murray JF (1972) Continuous positive pressure ventilation: effects on systemic oxygen transport and tissue oxygenation. Ann Intern Med 76:193–198
Manny J, Patten MT, Liebman PR, Hechtmann HB (1978) The association of lung distenion, PEEP and biventricular failure. Ann Surg 187:151–157
Morgan BC, Crawford EW, Guntheroth WG (1969) The hemodynamic effects of changes in blood volume during intermittent positive-pressure ventilation. Anesthesiology 30:297–305
Nachtwey W: Die künstliche Atmung bei ventilatorischen Notlagen im Gefolge interner Erkrankungen. Habilitationsschrift Hamburg-Altona
Nishimura N, Obayashi K, Takano T (1980) Hemodynamic effect of positive end-expiratory pressure (PEEP) in severe heart failure due to acute myocardial infarction (AMI). Crit Care Med 8:229
Qvist J, Pontoppidan H, Wilson RS, Lowenstein E, Laver MB (1975) Hemodynamic responses to mechanical ventilation with PEEP: The effect of hypervolemia. Anesthesiology 42:45–55
Schulz V, Schnabel KH, Erdmann W (1975) Beatmung mit positivem endexspiratorischem Druck — funktionsdiagnostische Untersuchungen und klinische Erfahrungen. Intensivmed 12:153–164
Shah DM, Newell JC, Dutton RE, Powers SR (1977) Continuous positive airway pressure versus positive end-expiratory pressure in respiratory distress syndrome. J Thorac Cardiovasc Surg 74:557–562
Simonneau G, Lemaire F, Harf A, Teisseire C, Teisseire B (1982) A comparative study of the cardiorespiratory effects of continuous positive airway pressure breathing and continuous positive pressure ventilation in acute respiratory failure. Intens Care Med 8:61–67
Snyder JV, Powner DJ (1982) Effects of mechanical ventilation on the measurement of cardiac output by thermodilution. Crit Care Med 10:677–682
Steinhoff H, Falke K, Schwarzhoff W (1982) Enhanced renal function associated with intermittent mandatory ventilation in acute respiratory failure. Intens Care Med 8:69–74
Suter PM, Fairley HB, Isenberg MD (1975) Optimum end-expiratory airway pressure in patients with acute pulmonary failure. N Engl Med 292:284–289
Thomas LJ, Roos A, Griffo ZJ (1961) Relation between alveolar surface tension and pulmonary vascular resistance. J Appl Physiol 16:457–462
Viquerat CE, Righetti A, Suter PM (1983) Biventricular volumes and function in patients with adult respiratory distress syndrome ventilated with PEEP. Chest 3:509–514
Weber KT, Janicki JS, Shroff S, Fishman AP (1981) Contractile mechanics and interaction of the right and left ventricles. Am J Cardiol 47:686–695
Weigelt JA, Mitchell RA, Snyder WH (1979) Early positive end-expiratory pressure in the adult respiratory distress syndrome. Arch Surg 114:497–501
Weilemann LS, Schuster HP, Schuster CJ, Rey C, Majdandzic J (1981) Verbesserung der Prognose bei Langzeitbeatmung durch frühzeitigen Einsatz von PEEP. Klin Wochenschr 59:607–612
Weisman IM, Rinaldo JE, Rogers RM (1982) Positive end-expiratory pressure in adult respiratory failure. N Engl J Med 307:1381–1384
Wolff G, Grädel E, Hasse J, Gasser D (1974) Günstige Auswirkungen der künstlichen Beatmung auf den großen und kleinen Kreislauf bei Linksherzinsuffizienz. Intensivmed 11:218–223
Wolff G, Langenstein H, Schwendener R, Lischer P (1982) Optimal endexpiratory airway pressure for ventilated patients. Intens Care Med 8:39–48
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Schuster, HP. Die hämodynamischen Auswirkungen der Überdruckbeatmung. Klin Wochenschr 62, 56–64 (1984). https://doi.org/10.1007/BF01769664
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DOI: https://doi.org/10.1007/BF01769664