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Cancer Immunology, Immunotherapy

, Volume 30, Issue 5, pp 300–306 | Cite as

Tumour-associated proliferative responses in vitro of regional lymph nodes draining solid cancers in man

  • T. Mainou-Fowler
  • O. Eremin
Original articles

Summary

The proliferative responses in vitro of tumourdraining lymph node lymphocytes were evaluated against autologous colon and lung carcinoma cells. The reactivity of lymphocytes appeared to be directed against tumour-associated rather than tumour-specific antigens. The lymphocyte reactivity detected was not due to an autologous mixed lymphocyte reaction. Recombinant interleukin-2 augmented the responses detected but not their tumour specificity. Phenotypic characterisation indicated the presence of T suppressor/cytotoxic (TS/C) cells as well as natural killer (NK) cells. Only the latter, however, were active in functional cytotoxicity assays. The inability to generate both tumour-specific proliferation of tumour-draining lymph node lymphocytes and tumour-specific cytotoxic killer cells may be due to the presence of suppressor cells in the regional lymph nodes; preliminary data suggest the presence of such cells.

Keywords

Carcinoma Lymph Node Carcinoma Cell Natural Killer Killer Cell 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag 1989

Authors and Affiliations

  • T. Mainou-Fowler
    • 1
  • O. Eremin
    • 1
  1. 1.Department of SurgeryUniversity of Aberdeen, University Medical BuildingsForesterhill, AberdeenUK

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