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Tumour-associated proliferative responses in vitro of regional lymph nodes draining solid cancers in man

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Summary

The proliferative responses in vitro of tumourdraining lymph node lymphocytes were evaluated against autologous colon and lung carcinoma cells. The reactivity of lymphocytes appeared to be directed against tumour-associated rather than tumour-specific antigens. The lymphocyte reactivity detected was not due to an autologous mixed lymphocyte reaction. Recombinant interleukin-2 augmented the responses detected but not their tumour specificity. Phenotypic characterisation indicated the presence of T suppressor/cytotoxic (TS/C) cells as well as natural killer (NK) cells. Only the latter, however, were active in functional cytotoxicity assays. The inability to generate both tumour-specific proliferation of tumour-draining lymph node lymphocytes and tumour-specific cytotoxic killer cells may be due to the presence of suppressor cells in the regional lymph nodes; preliminary data suggest the presence of such cells.

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Authors and Affiliations

  1. Department of Surgery, University of Aberdeen, University Medical Buildings, AB9 2ZD, Foresterhill, Aberdeen, Scotland, UK

    T. Mainou-Fowler & O. Eremin

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  1. T. Mainou-Fowler
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  2. O. Eremin
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Part of this project was supported by a grant from Cancer Research Campaign

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Mainou-Fowler, T., Eremin, O. Tumour-associated proliferative responses in vitro of regional lymph nodes draining solid cancers in man. Cancer Immunol Immunother 30, 300–306 (1989). https://doi.org/10.1007/BF01744898

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  • DOI: https://doi.org/10.1007/BF01744898

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