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The effect of air ions on bacterial and viral pneumonia in mice

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Abstract

Ambient air untreated for removal of ordinary pollutants and ionized with tritium powered generators to contain 1–2 × 105 small positive ions/cm3 accelerated the rate of death of mice challenged intranasally with measured doses of KLEBSIELLA PNEUMONIAE or of the PR8 strain of influenza virus. The differences between the cumulative mortality rates of controls and ion-treated animals were significant (p < 0.05 to p < 0.001) for several days of the period of observation. Exposure of infected mice to an electrical field of the same strength as that used for ion-treated mice showed no statistically significant field effect. Repetition of the influenza virus experiments using pollutant-free air and ion densities averaging 4.1 × 105 small positive ions/cm3 produced essentially the same results. The observation that high concentrations of positive ions accelerate the rate of death in pulmonary infections with KLEBSIELLA PNEUMONIAE and with influenza virus conforms to the pattern of earlier work with COCCIDIOIDES IMMITIS.

Zusammenfassung

Ungereinigte Umgebungsluft mit 1–2 × 105 kleinen positiven Ionen/cm3 nach Ionisation mit Tritiumbetriebenen Generatoren beschleunigte die Todesrate von Mäusen, die intranasal mit bekannten Mengen KLEBSIELLA PNEUMONIAE und PR8 Influenza Virus okuliert worden waren. Die Unterschiede zwischen den Kontrolltieren und den ionenbehandelten Tieren waren an mehreren Beobachtungstagen signifikant (p < 0,05 bis p < 0,001). Die Exponierung der infizierten Tiere in einem elektrischen Feld der gleichen Stärke, wie für die ionenbehandelten Tiere verwendet wurde, ergab keine statistischen Unterschiede. Die Wiederholung der Versuche mit Influenza Virus in reiner Luft mit 4,1 × 105 kleinen positiven Ionen/cm3 ergab die gleichen Ergebnisse.

Resume

De l'air non purifié additionné de 1–2 × 105 petits ions positifs/cm3 — ions provenant de générateurs au Trititium — a augmenté le taux de décès de souris qu'on avait au préalable infectées par le nez de quantités déterminées de KLEBSIELLA PNEUMONIAE et de virus d'influenza PR8. La différence du taux cumulatif de mortalité entre des animaux traités avec cet air ionisé et des témoins a été significative pour chacun des jours de la période d'essais (p < 0,05 à p < 0,001). L'exposition de souris infectées à un champ électrique de même intensité que celui utilisé pour les animaux traités n'a pas présenté d'effets significatifs. La répétition de l'essai avec le virus de l'influenza, mais en utilisant de l'air libre de tout polluant et une densité d'ions moyenne de 4,1 × 105 petits ions positifs/cm3 a conduit à des résultats similaires. La constatation que de hautes concentrations en ions positifs augmente le taux de décès dûs à des infections pulmonaires avec KLEBSIELLA PNEUMONIAE et avec le virus de l'influenza vient confirmer le résultat d'un essai antérieur pratiqué avec COCCIDIOIDES IMMITIS.

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References

  • ANDERSEN, I. (1969): The effect of ionized air on ciliary activity in trachea. Biometeorology 4. S.W. Tromp and W.H. Weihe (ed.), Swets & Zeitlinger, Amsterdam, Part II, 135.

    Google Scholar 

  • DELEANU, M., FRITS, T. and FLOREA, E. (1965): L'action de l'air ionisé dans le traitement des ulcères gastroduodenaux. Int.J.Biometeor., 9: 161–65.

    Google Scholar 

  • GUILLERM, BADRE, R. and HEE, J. (1966): A study in vitro of the action of light atmospheric ions on the ciliary activity of the tracheal epithelium. Ann. Pharm. Franc., 24:469–78.

    PubMed  Google Scholar 

  • HAINE, E., KÖNIG, H.L. and SCHMEER, J. (1964): Aphid moulting under controlled electrical conditions. Int. J. Biometeor., 7: 265–275.

    Google Scholar 

  • KNOLL, M., EICHMEIER, J., SCHÖN, R.W. (1964): Properties, measurement and bioclimatic action of "small" multimolecular atmospheric ions. Advances in Electronics and Electron Physics, 19: 177–253.

    Google Scholar 

  • KRUEGER, A.P. and SMITH, R.F. (1960a): The biological mechanisms of air ion action. I. 5-hydroxytryptamine as the endogenous mediator of positive air ion effects on the mammalian trachea. J. gen. Physiol., 43: 533–540.

    PubMed  Google Scholar 

  • KRUEGER, A.P. and SMITH, R.F. (1960b): The biological mechanisms of air ion action. II. Negative air ion effects on the concentration and metabolism of 5-hydroxytryptamine in the mammalian respiratory tract. J. gen. Physiol., 44: 269–276.

    PubMed  Google Scholar 

  • KRUEGER, A.P., KOTAKA, S. and ANDRIESE, P.C. (1962): Studies in the effects of gaseous ions on plant growth. I. The influence of positive and negative air ions on the growth of Avena sativa. J.gen.Physiol., 45: 879–895.

    PubMed  Google Scholar 

  • KRUEGER, A.P., ANDRIESE, P.C. and KOTAKA, S. (1963): The biological mechanisms of air ion action: The effect of CO +2 in inhaled air on the blood level of 5-hydroxytryptamine in mice. Int. J. Biometeor., 7: 3–16.

    Google Scholar 

  • KRUEGER, A.P., KOTAKA, S. and ANDRIESE, P.C. (1965): The effect of abnormally low concentrations of air ions on the growth of Hordeum vulgaris. Int.J.Biometeor., 9: 201–09.

    Google Scholar 

  • KRUEGER, A.P., ANDRIESE, P.C. and KOTAKA, S. (1966): The effects of inhaling non-ionized or positively ionized air containing 2–4% CO2 on the blood levels of 5-hydroxytryptamine in mice. Int.J.Biometeor., 10: 17–28.

    Google Scholar 

  • KRUEGER, A.P. and LEVINE, H.B. (1967): The effect of unipolar positively ionized air on the course of coccidioidomycosis in mice. Int.J.Biometeor., 11: 279–288.

    Google Scholar 

  • KRUEGER, A.P., ANDRIESE, P.C. and KOTAKA, S. (1968): Small air ions: their effect on blood levels of serotonin in terms of modern physical theory. Int.J.Biometeor., 12:255–239.

    Google Scholar 

  • NAUMOV (1965): Use of antibiotic electroaerosols in selected chronic diseases of the upper respiratory tract. Dissertation. Moscow.

  • PALTI, Y., DENOUR, E. and ABRAMOV, A. (1966): The effect of atmospheric ions on the respiratory system of infants. Pediatrics, 38: 405–411.

    PubMed  Google Scholar 

  • POGRUND, R.S. (1969): Biologic synergisms in rats produced by carbon monoxide and positive ions. Int.J.Biometeor., 13:123–134.

    Google Scholar 

  • REED, L.J. and MUENCH, H. (1938): A simple method of estimating fifty per cent endpoints. Amer.J.Hyg., 27: 493–497.

    Google Scholar 

  • ROBINSON, N. and DIRNFELD, F.S. (1963): The ionization state of the atmosphere as a function of the meteorological elements and of various sources of ions. Int.J.Biometeor., 6: 101–110.

    Google Scholar 

  • SEROVA, L.V. (1966): Changes in the resistance of tissues in animals inhaling ionized air. Vestnik Akademii Meditsinskikh Nauk SSR, 8: 39–44.

    Google Scholar 

  • SHARP, E.L. (1966): Biological effects of natural ionization, electrostatic, electromagnetic and magnetic fields of the atmosphere. Biometeorology 3. S.W. Tromp and W.H. Weihe (ed.), Swets & Zeitlinger, Amsterdam, 324.

    Google Scholar 

  • SHARP, E.L. (1967): Atmospheric ions and germination of uredospores of PUCCINIA STRIIFORMIS West. Science, 156: 1359–1360.

    PubMed  Google Scholar 

  • SILVERMAN, D. and KORNBLUEH, I.H. (1957): The effect of artificial ionization of the air on the electroencephalogram. Amer.J.Phys. Med., 36: 352–58.

    PubMed  Google Scholar 

  • WEHNER, A.P. (1969): Effect of electroaerosol inhalation on pulmonary clearance of239PuO2 in rats. Abstract. In: Biometeorology 4. S.W. Tromp and W.H. Weihe (ed.), Swets & Zeitlinger, Amsterdam, Part II, 93.

    Google Scholar 

  • WINSOR, T. and BECKETT, J.C. (1958): Biological effects of ionized air in man. Amer.J.Phys.Med., 37: 83–89.

    PubMed  Google Scholar 

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Krueger, A.P., Kotaka, S., Reed, E.J. et al. The effect of air ions on bacterial and viral pneumonia in mice. Int J Biometeorol 14, 247–260 (1970). https://doi.org/10.1007/BF01742068

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