Summary
Recently the bone-marrow cavity blood concentration of parathyroid hormone (PTH) has been shown to exceed that of the peripheral blood. As PTH is a primary modulator of bone cell activity, altered levels of the hormone in the bone-marrow blood may play a significant role in the aetiology of bone disease. We therefore measured PTH concentrations in marrow cavity and venous blood of 9 osteoporotic and 14 control subjects using sequence specific radioimmunoassays for intact and mid-carboxyl (Mid-C) regional human PTH (hPTH). Intact and Mid-C PTH levels were identical in the peripheral blood of control and osteoporotic subjects. Furthermore, bone-marrow cavity blood concentrations of Mid-C PTH, whilst universally higher than those found in peripheral blood, were also comparable in the osteoporotic and control subjects. The sole difference in the PTH composition of bone-marrow cavity blood from osteoporotic subjects was an increased concentration of intact PTH. The origins and consequences of elevated levels of intact PTH within the marrow cavity blood of osteoporotic subjects are discussed.
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Atkinson MJ, Bodenstein H, Hesch R-D (1983) Parathyroid hormone concentration gradients across the human bone marrow. Calcif Tissue Int 35:591–595
Atkinson MJ, Niepel B, Jüppner H, Casaretto M, Zahn H, Butz R, Hehrmann R, Hesch R-D (1981) Homologous radioimmunoassay for human mid-regional parathyroid hormone. J Endocrinol Invest 4:363–366
Atkinson MJ, Vido I, Keck E, Hesch R-D (1983) Hepatic osteodystrophy in primary biliary cirrhosis: a possible defect in Kupffer cell mediated, cleavage of parathyroid hormone. Clin Endocrinol (Oxf) 19:21–29
Atkinson MJ, Wong CC, Jüppner H (1982) A radioimmunoassay for intact human PTH using the synthetic peptide hPTH(28–48). Acta Endocrinol [Suppl] (Kbh) 246:138
Bar RS, Gorden P, Roth J, Siebert CW (1977) Insulin receptors in patients with insulinomas: Changes in receptor affinity and concentration. J Clin Endocrinol Metab 44:1210–1213
Edwards DJ, Rimmer JJ, Atkinson MJ, Perris AD (1982) Changes in plasma calcium and in bone marrow mitosis after antigenic challenge in rats and mice. J Endocrinol 90:444–452
Frost HM (1973) Bone remodelling and its relationship to metabolic bone disease. C.C. Thomas, Illinois
Hollingsworth JW (1968) Local and systemic complications of rheumatoid arthritis. W.B. Saunders, Philadelphia, pp 74–76
Howard GA, Bottemiller BL, Turner RT, Rader JI, Baylink DJ (1981) Parathyroid hormone stimulates bone formation and resorption in organ culture. Evidence for a coupling mechanism. Proc Natl Acad Sci (USA) 78:3204–3208
Jüppner H, Rosenblatt M, Segre GV, Hesch RD (1983) Discrimination between intact and mid-C-regional PTH using selective assay systems. Acta Endocrinol (Kbh) 102:543–549
Kahn CR (1976) Membrane receptors for hormones and neurotransmitters. J Cell Biol 70:261–286
Knobil E (1980) The neuroendocrine control of the menstrual cycle. Recent Prog Horm Res 36:53–88
Lilienfeld-Toal H von, Hesch R-D, Hufner M, McIntosch C (1974) Excretion of 3′5′ adenosine cyclic monophosphate in renal insufficiency and primary hyperparathyroidism after stimulation with parathyroid hormone. Horm Metab Res 6:315–318
Martin KJ, Hruska KA, Freitag JJ, Klahr S, Slatopolsky E (1979) The peripheral metabolism of parathyroid hormone. N Eng J Med 301:1092–1098
Olgaard K, Arbelaez M, Schwartz J, Klahr S, Slatopolsky E (1982) Abnormal skeletal response to parathyroid hormone in dogs with chronic uremia. Calcif Tissue Int 34:403–407
Parsons JA (1969) Parathyroid hormone physiology and the skeleton. In: Bourne GH (Hrsg). The biochemistry and physiology of bone. Academic Press, New York, pp 159–225
Parsons JA, Robinson CJ (1968) A rapid indirect hypercalcaemic action of PTH demonstrated in isolated perfused bone. In: Talmage RV, Belangers LF (Hrsg). Parathyroid hormone and calcitonin. Excerta Medica, Amsterdam, pp 329–331
Peck WA, Kohler G (1980) Hormonal and nonhormonal desensitisation in isolated bone cells. Calcif Tissue Int 32:95–103
Ramsay NKC, Brown DM, Nesbitt ME, Coccia PF, Krivit W, Krutzik S (1979) Autonomous production of parathyroid hormone by lymphoblastic leukemia cells in culture. J Pediatr 94:623–625
Reeve J, Meunier PJ, Parsons JA, et al. (1980) Anabolic effects of human parathyroid hormone fragment on trabecular bone in involutional osteoporosis, a multicenter trial. Br Med J 1:1340–1344
Schettler T, Atkinson MJ, Bodenstein H (1983) Characterisation of human leukaemic blast cell parathyroid hormone. Acta Endocrinol (Suppl) (Copenh) 252:22
Segre GV, Perkins AS, Witters LA, Potts JT (1981) Metabolism of parathyroid hormone by isolated rat Kupffer cells and hepatocytes. J Clin Invest 67:449–457
Slovik DM, Neer RM, Potts JT (1981) Short term effects of synthetic human parathyroid hormone (1–34) on bone mineral metabolism in osteoporotic patients. J Clin Invest 68:1261–1267
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Supported by the Deutsche Forschungsgemeinschaft and the Stiftung Volkswagenwerk
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Atkinson, M.J., Schettler, T., Bodenstein, H. et al. Osteoporosis: A bone turnover defect resulting from an elevated parathyroid hormone concentration within the bone-marrow cavity?. Klin Wochenschr 62, 129–132 (1984). https://doi.org/10.1007/BF01738703
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DOI: https://doi.org/10.1007/BF01738703