Summary
The effect of cimetidine, an inhibitor of suppressor T lymphocytes, on the burst-promiting activity (BPA) of normal T lymphocytes has been studied. Cimetidine has been shown to increase the BPA of normal T lymphocytes, both when added to the culture and when T lymphocytes were preincubated for 1 h with it. Cimetidine had no direct effect on the in vitro growth of burstforming units (BFU-E). Our results show that CD 8 suppressor T lymphocytes inhibit the in vitro growth of BFU-E in normal conditions, either directly or through inhibition of BPA of CD 4 helper T lymphocytes. Cimetidine has proved to be a useful tool for investigating the hematological role of T-lymphocyte subsets in normal and pathological conditions.
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This work was supported by a grant of theMinistem delta Ricerca Scientifica e Tecnologica, Italy
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Morra, L., Moccia, F., Casti, P. et al. Effect of cimetidine on burst-promoting activity of normal T lymphocytes. Ann Hematol 64, 221–223 (1992). https://doi.org/10.1007/BF01738300
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DOI: https://doi.org/10.1007/BF01738300