Summary
A challenging theme in bioorganic chemistry is the unification of established theories of biochemistry and organic chemistry to provide new patterns for interpretation and experimentation. Especially relevant examples of such interactions can be drawn from the field of enzyme catalysis and, in particular, the role of cofactors therein.
Knowledge of the chemical mechanisms by which some of the cofactors function has progressed rapidly with the aid of studies of the cofactors themselves (or compounds of related structure, “models”) stripped of the accompanying apoenzyme. The striking successes in this field likely arise from a fundamental resemblance between bioorganic chemistry (especially coenzyme models) and chemical evolution before the appearance of coded polypeptide enzymes.
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References
Blondin, G.A., Green, D.E. (1975). Chem. Eng. New. Nov. 1975, 26
Breslow, R. (1972). Chem. Soc. Rev.1, 553
Breslow, R. (1973). J. Am. Chem. Soc.95, 3251
Breslow, R. (1974). J. Am. Chem. Soc.96, 1973
Bruice, T.C., Benkovic, S.J. (1966). Bioorganic Mechanisms. New York: Benjamin
Bryson, V., Vogel, H.J., ed. (1965). Evolving genes and proteins. New York: Academic Press
Cairns-Smith, A.J., Walker, G.L. (1974). Bio systems5, 1973
Eigen, M. (1971). Naturwissenschaften58, 465
Glansdorff, P., Prigogine, I. (1971). Thermodynamic theory of structure, stability and fluctuations. New York: Wiley
Heitler, W. (1961). Der Mensch und die Naturwissenschaftliche Erkenntnis. Braunschweig: Vieweg
Herschkowitz-Kaufman, M. (1970). Comptes Rendues Acad. Sc. Paris, Série C,270, 1049
Jencks, W.P. (1969). Catalysis in chemistry and enzymology, New York: McGraw-Hill
Jencks, W.P., Page, M.I. (1972). In: Enzymes: structure and function, Proc. 8th Fed. Eur. Biochem. Soc. Mtg, J. Drenth, ed., p. 45. Amsterdam: North-Holland Publ. Comp.
Kellogg, R.M. (1975). The evolution of organic chemistry. Groningen: Wolters-Noordhoff
Lienhard, G.E. (1973). Science180, 149
Lindquist, R.N. (1975). The Design of Enzyme Inhibitors: Transition State Analogs. In: Drug design, vol. V, Ariēns, ed., p. 23
Monod, J. (1970). Le hasard et la nécessité. Paris: Ed. du Seuil
Pauling, L. (1948). American Scientist36, 58
Prigogine, I. (1945). Bull. Classe Sci. Acad. Roy. Belg.31, 600
Prigogine, I., Wiame, J.M. (1946). Experientia2, 451
Prigogine, I. (1967). Introduction to thermodynamics of irreversible processes. New York: Wiley
Prigogine, I., Lefever, R. (1971). Thermodynamics, structure and dissipation. In: Experientia Suppl.18, p. 101
Prigogine, I. (1972). Recherche3, (24), 547, 559
Prigogine, I., Babloyantz, A. (1972). FEBS Proceedings Mtg25, 3
Prigogine, I., Nicolis, G., Babloyantz, A. (1972). Physics todayNov., 23; Dec., 38
Prigogine, I., Lefever, R. (1973). Theory of Dissipative Structures. In: Synergetics, Coop. Phenomena Multi-component syst., Proc. Symp., 1st1972, H. Haken ed., p. 124, Stuttgart
Robinson, R. (1917a). J. Chem. Soc.111, 762
Robinson, R. (1917b). J. Chem. Soc.111, 876
Schoffeniels, E., ed. (1971). Biochemical evolution and the origin of life. Amsterdam: North-Holland Publ. Comp.
Schrödinger, E. (1956). What is life?, and other scientific essays. New York: Doubleday
Skinner, K.J. (1975). Chem. Eng. News.Aug. 22
Wolfenden, R. (1972). Accounts of Chem. Res.5, 10
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Visser, C.M., Kellogg, R.M. Bioorganic Chemistry and the Origin of Life. J Mol Evol 11, 163–169 (1978). https://doi.org/10.1007/BF01733891
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DOI: https://doi.org/10.1007/BF01733891