Summary
The weight of the human spleen decreases in old age. The percentage of erythrocytes with pits observed by interference contrast microscopy was significantly higher in 39 elderly subjects (median 4.2%, range 1.2%–14.6%) than in 34 younger controls (median 1.4%, range 0.6%–6.2%). Further evidence of splenic hypofunction was obtained from 7 elderly people with increased pit counts: the removal from circulation and accumulation into the spleen of heat-damaged autologous erythrocytes was abnormally slow. However, no difference in the spleen area of the same subjects measured by scintillation scanning was observed in comparison with normals. Thus, the weight reduction of spleen in old age is accompanied by a decrease in splenic function.
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Casper JT, Koethe S, Rodey GE, Thatcher LG (1976) A new method for studying splenic reticuloendothelial dysfunction in sickle cell disease patients and its clinical application: a brief report. Blood 47:183–188
Coleman N, McDougall IR, Dailey MO, Ager P, Bush S, Kaplan HS (1982) Functional hyposplenia after splenic irradiation for Hodgkin's disease. Ann Intern Med 96:44–47
Dacie JV, Lewis SM (1975) Practical haematology. 5th edn. Churchill Livingstone, London
Dameshek W (1955) Hyposplenism. JAMA 157:613
Eichner ER (1979) Splenic function: normal, too much and too little. Am J Med 66:311–320
Eraklis AJ, Kevy SV, Diamond LK, Gross RE (1967) Hazard of overwhelming infection after splenectomy in childhood. N Engl J Med 276:1225–1228
Halpert B, Györkey F (1959) Lesions observed in accessory spleens of 311 patients. Am J Clin Pathol 32:165–168
Holroyde CP, Gardner FH (1970) Acquisition of autophagic vacuoles by human erythrocytes. Physiologic role of the spleen. Blood 36:566–575
Holroyde CP, Oski FA, Gardner FH (1969) The “pocked” erythrocyte: red-cell surface alterations in reticuloendothelial immaturity of the neonate. N Engl J Med 281:516–520
Krumbhaar EB, Lippincot SW (1939) The postmortem weight of the “normal” human spleen at different ages. Am J Med Sci 197:344–358
Lipson RL, Bayrd ED, Watkins CH (1959) The postsplenectomy blood picture. Am J Clin Pathol 32:526–532
Marsh GW, Lewis SM, Szur L (1966) The use of51Cr-labelled heat-damaged red cells to study splenic function. I. Evaluation of the method. Br J Haematol 12:161–166
Marsh GW, Stewart JS (1970) Splenic function in adult coeliac disease. Br J Haematol 19:445–457
Nielsen JL (1982) Influence of residual splenic tissue on the presence of vacuolated erythrocytes in splenectomized patients. Scand J Haematol 28:451–455
Pearson HA, McIntosh S, Ritchey AK, Lobel JS, Rooks Y, Johnston D (1979) Developmental aspects of splenic function in sickle-cell diseases. Blood 53:358–365
Pearson HA, Spencer RP, Cornelius EA (1969) Functional asplenia in sickle-cell anemia. N Engl J Med 281:923–926
Ryan FP, Smart RC, Holdsworth CD, Preston FE (1978) Hyposplenism in inflammatory bowel disease. Gut 19:50–55
Sills RH, Oski FA (1979) RBC surface pits in sickle hemoglobinopathies. Am J Dis Child 133:526–527
Verheyden CN, Beart RW, Clifton MD, Phyliky RL (1978) Accessory splenectomy in management of recurrent idiopathic thrombocytopenic purpura. Mayo Clin Proc 53:442–446
Williams WJ (1977) Hematology in the aged. In: Williams WJ, Beutler E, Erslev AJ, Rundles RW (eds) Hematology. 2nd edn. McGraw-Hill, New York, pp 49–54
Zago MA, Bottura C (1983) Splenic function in sickle-cell diseases. Clin Sci 65:297–302
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This work was partly supported by Fundação de Amparo ã Pesquisa do Estado de São Paulo, Brazil
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Zago, M.A., Figueiredo, M.S., Covas, D.T. et al. Aspects of splenic hypofunction in old age. Klin Wochenschr 63, 590–592 (1985). https://doi.org/10.1007/BF01733010
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DOI: https://doi.org/10.1007/BF01733010