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The mechanism of lipid-binding by plasma lipoproteins

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Summary

In this article, we review the current state of knowledge about the structure of human plasma high density lipoproteins. Recent advances in this field, including amino acid sequencing and lipid-binding studies, suggest that the plasma lipoproteins have specific sites with special structural features that account for their ability to bind and transport lipid. A hypothesis which describes the structure of these lipid-binding sites and their interaction with lipid is presented.

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Authors and Affiliations

  1. Department of Medicine, Baylor College of Medicine and The Methodist Hospital, 77025, Houston, Texas, USA

    Richard L. Jackson, Joel D. Morrisett & Antonio M. Gotto Jr.

  2. Laboratory of Experimental Pathology, National Institute of Arthritis and Metabolic Diseases, National Institutes of Health, 20014, Bethesda, Maryland, USA

    Jere P. Segrest

Authors
  1. Richard L. Jackson
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  2. Joel D. Morrisett
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  3. Antonio M. Gotto Jr.
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  4. Jere P. Segrest
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Additional information

This work was supported in part by Health Education and Welfare Grant No. 14194, by a grant from the John A. Hartford Foundation, Inc., by The American Heart Association, Texas Affiliate, by a NIH Cardiovascular Research and Training Center Grant No. 05435, and by a NIH General Clinical Research Center Grant No. RR-00350.

An invited article.

Established Investigators of The American Heart Association.

§ Present address: Department of Pathology, University of Alabama, Birmingham, Alabama.

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Jackson, R.L., Morrisett, J.D., Gotto, A.M. et al. The mechanism of lipid-binding by plasma lipoproteins. Mol Cell Biochem 6, 43–50 (1975). https://doi.org/10.1007/BF01731865

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  • DOI: https://doi.org/10.1007/BF01731865

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