Klinische Wochenschrift

, Volume 65, Issue 13, pp 590–595 | Cite as

Abfall der Serumlipoproteine und Anstieg der Apolipoproteine A-I und A-II nach oraler Zufuhr mehrfach ungesättigter Phospholipide

Beobachtungen zum Einfluß der Ernährung auf die Ergebnisse
  • W. Spann
  • G. Wolfram
  • N. Zöllner
Originalien

Abkürzungen

PPC

Polyenylphosphatidylcholin

VLDL

Very low density lipoproteins

LDL

Low density lipoproteins

HDL

High density lipoproteins

LCAT

Lecithin-Cholesterin-Acyl-Transferase

Decrease of serum lipoproteins and increase of apolipoproteins A-I and A-II following oral supply of polyenylphosphatidylcholine. Observations on influence of diet

Summary

Polyenylphosphatidylcholine was given orally in a dosage of 10 g per day to 10 healthy subjects for 4 weeks. The concentrations of cholesterol, triglycerides, phospholipids, apolipoproteins AI, AII, and B were measured in serum, as were very low density lipoproteins, low density lipoproteins, and high density lipoproteins every 3 h on the day before and after the 4 weeks of application. The diet was controlled 10 days before and during the experiment using the dietary recall method. The evaluation of the diet records showed that 5 subjects had increased and 5 subjects had decreased their fat consumption in exchange for carbohydrates during the experiment. Nevertheless body weight remained constant within ±1 kg. Cholesterol in serum and low density lipoprotein decreased, but the differences were not statistically significant. In spite of dietary changes apolipoprotein AI and AII in high density lipoproteins increased significantly. We conclude that the influence of drugs on serum lipids can only be evaluated in conjunction with reliable control of the diet.

Key words

Polyenylphosphatidylcholine Serum lipoproteins Nutrition 

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Copyright information

© Springer-Verlag 1987

Authors and Affiliations

  • W. Spann
    • 1
  • G. Wolfram
    • 1
    • 2
  • N. Zöllner
    • 1
  1. 1.Medizinische Poliklinik der Universität MünchenGermany
  2. 2.Institut für Ernährungswissenschaft der Technischen Universität MünchenGermany

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