Summary
Polyenylphosphatidylcholine was given orally in a dosage of 10 g per day to 10 healthy subjects for 4 weeks. The concentrations of cholesterol, triglycerides, phospholipids, apolipoproteins AI, AII, and B were measured in serum, as were very low density lipoproteins, low density lipoproteins, and high density lipoproteins every 3 h on the day before and after the 4 weeks of application. The diet was controlled 10 days before and during the experiment using the dietary recall method. The evaluation of the diet records showed that 5 subjects had increased and 5 subjects had decreased their fat consumption in exchange for carbohydrates during the experiment. Nevertheless body weight remained constant within ±1 kg. Cholesterol in serum and low density lipoprotein decreased, but the differences were not statistically significant. In spite of dietary changes apolipoprotein AI and AII in high density lipoproteins increased significantly. We conclude that the influence of drugs on serum lipids can only be evaluated in conjunction with reliable control of the diet.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
Abbreviations
- PPC:
-
Polyenylphosphatidylcholin
- VLDL:
-
Very low density lipoproteins
- LDL:
-
Low density lipoproteins
- HDL:
-
High density lipoproteins
- LCAT:
-
Lecithin-Cholesterin-Acyl-Transferase
Literatur
Beil FU, Grundy SM (1980) Studies on plasma lipoproteins during absorption of exogenous lecithin in man. J Lipid Res 21:525–536
Childs M, Bowlin JA, Ogilvie JT, Hazzard WR, Albers JJ (1981) The Contrasting Effects of a Dietary Soya Lecithin Product and Corn Oil on Lipoprotein Lipids in Normolipidemic and Familial Hypercholesterolemic Subjects. Atherosclerosis 38:217–228
Ditschuneit H, Klör H-U, Ditschuneit HH (1976) Effects of essential phospholipids on the carbohydrate-induced hypertriglyceridemia. In: Peeters H (ed) Phosphatidylcholine — Biochemical and Clinical Aspects of Essential Phospholipids, Springer, Berlin
Glomset JA (1968) The plasma lecithin cholesterol acyltransferase reaction. J Lipid Res 9:155–161
Greten H, Raetzer H, Stiehl A, Schettler G (1980) The Effect of Polyunsaturated Phosphatidylcholine on Plasma Lipids and Fecal Sterol Excretion. Atherosclerosis 36:81–88
Havel RJ, Eder HA, Bragdon JH (1955) The distribution and chemical composition of ultracentrifugally separated lipoproteins in human serum. J Clin Invest 34:1345–1353
Karst H, Möhr M, Seppelt B (1979) Das Ernährungsinterview. Nahrung 23:53–62
Kay RM, Rao S, Arnott C, Miller NE, Lewis B (1980) Acute Effects of the Pattern of Fat Ingestion on Plasma High Density Lipoprotein Components in Man. Atherosclerosis 36:567–573
Lekim D (1976) On the pharmacokinetics of orally applied essential phospholipids (EPL). In: Peeters H (ed) Phosphatidylcholine — Biochemical and Clinical Aspects of Essential Phospholipids. Springer, Berlin, pp 48–65
Lewis B (1981) Genes and Nutrition in the Regulation of Human Lipoprotein Metabolism. Klin Wochenschr 59:1037–1042
Mao SJT, Jackson RC, Gotto AM, Sparrow JT (1981) Mechanism of lipid-protein interaction in the plasma lipoproteins: Identification of a lipid-binding site in apolipoprotein A-II. Biochemistry 20:1676–1682
Nikkilä EA (1978) Metabolic regulation of plasma high density lipoprotein concentrations. Eur J Clin Invest 8:111–113
Peeters H, Blaton V, Soetewey F, Declercq B, Vandamme D (1973) Wirkung der „essentiellen“ Phospholipide auf Plasmalipide und Fettsäuren beim Typ II der Hyperlipoproteinämie. Münch Med Wochenschr 115:1358–1361
Rosseneu M, Declercq B, Vandamme D, Vercaemst R, Soetewey F, Peeters H, Blaton V (1979) Influence of oral Polyunsaturated and Saturated Phospholipid Treatment on the Lipid Composition and Fatty Acid profile of Chimpanzee Lipoproteins. Atherosclerosis 32:141–153
Sachs L (1984) Angewandte Statistik. Springer, Berlin
Schlierf G, Raetzer H (1972) Diurnal Patterns of Blood Sugar, Plasma Insulin, Free Fatty Acid and Triglyceride Levels in Normal Subjects and in Patients with Type IV Hyperlipoproteinemia and the Effect of Meal Frequency. Nutr Metabol 14:113–126
Simonsson P, Nilsson Ä, Äkesson B (1982) Postprandial effects of dietary phosphatidylcholine on plasma lipoproteins in man. Am J Clin Nutr 35:36–41
Soutar A, Garner C, Baker HN, Sparrow JT, Jackson RL, Gotto AM, Smith LC (1975) The effects of plasma apolipoproteins on lecithin cholesterol acyltransferase. Biochemistry 14:3057–3063
Tall AR, Small DM (1978) Plasma High-Density Lipoproteins. New Engl J Med 30:1232–1236
Utermann G, Hees H, Steinmetz A (1977) Polymorphism of Apolipoprotein E and occurence of dysbetalipoproteinemia in man. Nature 269:604–607
Wirths W, Rottka H, Anders H, Beck P, Meseburg D, Nourney M, Steller W (1979) Vergleich von Methoden zu Untersuchungen über Verzehrsgewohnheiten. Akt Ernährungsmed 2:61–67
Zierenberg O, Assmann G, Schmitz G, Rosseneu M (1981) Effect of Polyenephosphatidylcholine on Cholesterol Uptake by Human High Density Lipoprotein. Atherosclerosis 39:527–542
Zierenberg O, Odenthal J, Betzing H (1979) Incorporation of Polyenephosphatidylcholine into Serum Lipoproteins after oral or intravenous Administration. Atherosclerosis 34:259–276
Zierenberg O, Grundy M (1982) Intestinal Absorption of Polyenephosphatidylcholine in Man. J Lipid Res 23:1136–1142
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Spann, W., Wolfram, G. & Zöllner, N. Abfall der Serumlipoproteine und Anstieg der Apolipoproteine A-I und A-II nach oraler Zufuhr mehrfach ungesättigter Phospholipide. Klin Wochenschr 65, 590–595 (1987). https://doi.org/10.1007/BF01726664
Received:
Revised:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF01726664