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Ergebnisse der klinischen Prüfung des Glukoneogenesehemmers 2-(3-Methylcinnamylhydrazono)-Propionat (MCHP)

Clinical trial with the gluconeogenesis inhibitor 2-(3-Methylcinnamylhydrazono)-Propionat (MCHP)

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Summary

Many compounds which directly or indirectly inhibit gluconeogenesis have been described. Some of them showed hypoglycemic action in animal experiments.

2-(3-Methylcinnamylhydrazono)-Propionat (MCHP) a derivative of hydrazine demonstrated marked hypoglycemic action in animal experiments. Nontheless the administration of MCHP to type II diabetic patients showed no hypoglycemic action. Clinical or biochemical sideeffects could not be observed.

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Abbreviations

MCHP:

2-(3-methylcinnamylhydrazono)-Propionat

yGT:

Gamma-Glutamyl-Transferase

GOT:

Aspartataminotransferase

GPT:

Glutamyltranspeptidase

HDL-Cholesterin:

High density Lipoprotein-Cholesterin

BZ:

Blutzucker

Literatur

  1. Adnitt PI (1968) Hypoglycemic Action of Monoamineoxidase Inhibitors. Diabetes 17:628–633

    Google Scholar 

  2. Deaciuc IV, Kühnle HF, Strauss KM, Schmidt FH (1983) Studies on the mechanism of action of the hypoglycemic agent, 2-(3-Methylcinnamylhydrazono)-propionate (BM 42.304). J Pharmacol 32:3405–3412

    Google Scholar 

  3. Dimitriadis G, Raptis S, Hatziagelaki E, Mitrakou A, Halvatsiotis P, Ladas S, Hillebrand I (1986) Effects of two new a-glycosidase inhibitors on glycemic control in patients with insulin-dependent diabetes mellitus. Klin Wochenschr 64:405–410

    Google Scholar 

  4. Di Tullio NW, Berkhoff CE, Blank B, Kostos V, Stack EJ, Saunders HL (1974) 3-Mercaptopicolinic acid, an inhibitor of gluconeogenesis. Biochem J 138:387–394

    Google Scholar 

  5. Haeckel R, Oellerich M (1977) The influence of hydrazine, phenelzine and nialamide on gluconeogenesis and cell respiration in the perfused guinea-pig liver. Eur J Clin invest 7:393–400

    Google Scholar 

  6. Haeckel R, Oellerich M (1979) Hydrazonopropionic acids, a new class of non-hormonal hypoglycemic compounds. Biochem Soc Trans 7:749–752

    Google Scholar 

  7. Haeckel R, Oellerich M (1979) Hydrazonopropionic acids, a new class of hypoglycemic substances. 1. Hypoglycemic Effect of 2-(Phenylethylhydrazono)- and 2-(2-Cyclohexyl-ethylhydrazono)-pripionic acid. Horm metab Res 11:606–611

    Google Scholar 

  8. Haeckel R, Terlutter H, Schuhmann G, Oellerich M (1984) Hydrazonopropionic acids, a new class of hypoglycemic substances. 3. Inhibition of jejunal glucose uptake in the rat and guinea pig. Horm metab Res 16:423–427

    Google Scholar 

  9. Haeckel R, Oellerich M, Schuhmann G, Beneking M (1985) Hydrazonopropionic acids, a new class of hypoglycemic substances. 5. Inhibition of hepatic gluconeogenesis by 2-(3-Methylcinnamyl-Hydrazono)-propionate in the rat and guinea pig. Horm metab Res 17:115–122

    Google Scholar 

  10. Kean EA, Pogson CI (1979) Inhibition of gluconeogenesis in isolated rat liver cells by Methylenecyclopropylpyruvate (Ketohypoglycin). Biochem J 182:789–796

    Google Scholar 

  11. Kühnle HF, Schmidt FH, Deaciuc IV (1984) in vivo and in vitro effects of a new hypoglycemic agent. 2-(3-Methylcinnamylhydrazono)-propionate (BM 42.304) on glucose metabolism in guinea pigs. Biochem Pharmac 33:1437–1444

    Google Scholar 

  12. Mapes JP, Harris RA (1976) Inhibition of gluconeogenesis and lactate formation from pyruvate by N6O2-Dibutyryl Adenosine 3′:5′-Monophosphate. J Biol Chem 215:6189–6196

    Google Scholar 

  13. Oellerich M, Haeckel R (1980) Hydrazonopropionic acids, a new class of hypoglycemic substances. 2. Influence of 2-(Phenylethylhydrazono) and 2-(2-Cyclohexyl-ethylhydrazono)-propionic acid on redox systems, acid base status and monoamino oxidase activity. Horm metab Res 12:182–189

    Google Scholar 

  14. Oellerich M, Haeckel R, Schuhmann G (1980) Hydrazonoverbindungen — eine neue Gruppe von blutglucosesenkenden Substanzen. Aktuel Endokrinol Stoffw 1:214–215

    Google Scholar 

  15. Oellerich M, Haeckel R, Wirries K-H, Schuhmann G, Beneking M (1984) Hydrazonopropionic acids, a new class of hypoglycemic substances. 4. Hypoglycemic effect of 2-(3-Methylcinnamylhydrazono)-propionate in the rat and guinea pig. Horm metab Res 16:619–625

    Google Scholar 

  16. Van Praag HM, Leijnse B (1963) The influence of some antidepressives of the hydrazine type on the glucose metabolism in depressed patients. Clin Chim Acta 8:466–475

    Google Scholar 

  17. Tutwiler GF, Kirsch T, Mohrbacher RJ, Ho W (1978) Pharmacologic profile of Methyl-2-Tetradecylglycidate (McN-3716) — an orally effective hypoglycemic agent. Metabolism 27:1539–1555

    Google Scholar 

  18. Tutwiler GF, Brentzel HJ (1980) Effect of oral hypoglycemic agent, Pirogliride, on gluconeogenesis. Biochem pharmacol 29:1421–1427

    Google Scholar 

  19. Tutwiler GF, Brentzel HJ (1982) Relation of oxidation of long-chain fatty acids on gluconeogenesis in the perfused liver of guinea pig: Effect of 2-Tetradecylglycidic acid (McN-3802). Eur J Biochem 124:465–470

    Google Scholar 

  20. Wolf HPO, Eistetter K, Ludwig G (1982) Phenylalkyloxirane carboxylic acids, a new class of hypoglycemic substances: hypoglycaemic and hypoketonaemic effects of Sodium 2-(5-(4-Chlorophenyl)-pentyl)-oxirane-2-carboxylate (B 807-27) in fasted animals. Diabetologia 22:456–463

    Google Scholar 

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Authors and Affiliations

  1. II. Medizinische Klinik, Klinikum Mannheim der Universität Heidelberg, Mannheim

    R. Paschke, U. Schwedes, J. Peter, R. Schmeidl & K. H. Usadel

  2. Boehringer Mannheim GmbH, Medizinische Forschung, Stoffwechsel, Mannheim

    H. Kühnle

Authors
  1. R. Paschke
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  2. U. Schwedes
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  3. H. Kühnle
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  4. J. Peter
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  5. R. Schmeidl
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  6. K. H. Usadel
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Paschke, R., Schwedes, U., Kühnle, H. et al. Ergebnisse der klinischen Prüfung des Glukoneogenesehemmers 2-(3-Methylcinnamylhydrazono)-Propionat (MCHP). Klin Wochenschr 67, 431–437 (1989). https://doi.org/10.1007/BF01725138

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  • DOI: https://doi.org/10.1007/BF01725138

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