Abstract
We have studied the prevalence of antimicrobial resistance ofStreptococcus pneumoniae in Southwest Germany. One hundred seventy-four clinical isolates of pneumococci collected from hospitalized patients between October 1992 and April 1994 were used for MIC determinations. MICs for penicillin, ceftriaxone, erythromycin, and rifampicin were assessed by the E test. Eleven of the 174 strains (6.3%) were intermediately resistant to penicillin (MIC between 0.1 and 1.0 µg/ml) and four of the 174 strains (2.3%) were intermediately resistant to ceftriaxone (MIC between 0.1 and 1.0 µg/ml). All four isolates with a reduced susceptibility to ceftriaxone also demonstrated intermediate resistance to penicillin. Six of the 174 strains (3.5%) were highly resistant (MIC ⩾8 µg/ml) to erythromycin. Resistance to rifampicin was not observed. Our results demonstrate that pneumococcal resistance to penicillin and erythromycin has increased markedly in Germany over the last decade. Our findings underline the need for continuous surveillance of antimicrobial resistance ofStreptococcus pneumoniae.
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References
Appelbaum PC. World-wide development of antibiotic resistance in pneumococci. Eur J Clin Microbiol 1978; 6: 367–377.
Hansmann D, Bullen MM. A resistant pneumococcus. Lancet 1987(ii): 264–265.
Klugman K. Pneumococcal resistance to antibiotics. Clin Microbiol Rev 1990; 3: 171–196.
Jacobs MD, Koornhof HJ, Robins-Browne RM. Emergence of multiply resistant pneumococci. New Engl J Med 1978; 299: 735–740.
Bradley JS, Connor JD. Ceftriaxone failure in meningitis caused byStreptococcus pneumoniae with reduced susceptibility to beta-lactam antibiotics. Ped Infect Dis J 1991; 10: 871–873.
Klugman KP, Saunders J. Pneumococci resistant to extended-spectrum cephalosporins in South Africa. Lancet 1993 (i): 1164.
Linares J, Alonso T, Perez JS. Decreased susceptibility of penicillin-resistant pneumococci to 24 beta-lactam antibiotics. J Antimicrob Chemother 1992; 30: 279–288.
Ward J. Antibiotic-resistantStreptococcus pneumoniae: Clinical and epidemiological aspects. Rev Infect Dis 1981; 3: 254–266.
Clarke RB, Giger O, Mortensen JE. Comparison of susceptibility test methods to detect penicillin-resistantStreptococcus pneumoniae. Diagn Microbiol Infect Dis 1993; 17: 213–217.
Jacobs MD, Bajaksouzian S, Appelbaum PC, Bolmström A. Evaluation of the E test for susceptibility testing of pneumococci. Diagn Microbiol Infect Dis 1992; 15: 473–478.
Jorgensen JH, Howell AW, Maher LA. Quantitative antimicrobial susceptibility testing ofHaemophilus influenzae and Streptococcus pneumoniae by using the E test. J Clin Microbiol 1991; 29: 109–114.
Facklam RR, Washington II JA. Streptococcus and related catalase-negative Gram-positive cocci. In Balows A, Hausler WJ, Hermann KL. Isenberg HD, Shadomy JJ, eds. Manual of clinical microbiology, 5th ed., Washington DC: American Society of Microbiology, 1991; 238–257.
Klugman KP, Koornhof JJ. Worldwide increase in pneumococcal antibiotic resistance. Lancet 1989(ii): 444.
Arctic Investigation Laboratory Centers for Disease Control (A1L CDC). Partial penicillin resistant pneumococcal isolates recovered from Alaskan patients. Alaska Medicine 1987; 29: 186–187.
Casal J, Fenoll A, Vicioso MS, Munoz R. Increase in resistance to penicillin in pneumococci in Spain. Lancet 1989 (i): 735.
Marton A. Pneumococcal antimicrobial resistance: the problem in Hungary. Clin Infect Dis 1992; 15: 106–111.
Hakenbeck R, Reichmann P, Sibold C. Evolution and spread of β-lactam resistantStreptococcus pneumoniae. Klin Lab 1994; 40: 230–235.
Geslin P, Buu-Hoi A, Fremaux A, Acar JF. Antimicrobial resistance inStreptococcus pneumoniae: An epidemiological survey in France, 1970–1990. Clin Infect Dis 1992; 15: 95–98.
Verhaegen J, Goubau P, Verbist L, Glupczynsky J, Blogie M, Yourassowsky E. Erythromycin-resistantStreptococcus pneumoniae. Lancet 1988(ii): 1432–1433.
Kaufhold A, Lütticken R, Henrichsen J. Capsular types and antibiotic susceptibility ofStreptococcus pneumoniae isolated from patients with systemic infections in West Germany. Eur J Clin Microbiol 1987; 6: 696–697.
Milatovic D, Machka K, Heck W, Braveny J. Serotypes and antimicrobial susceptibility ofStreptococcus pneumoniae in West Germany. Infection 1981; 9: 220–222.
Reinert RR, Lütticken R, Kaufhold A. Aktuelle Daten zur Antibiotikaempfindlichkeit vonStreptococcus pneumoniae. Med Klinik 1993; 88: 357–361.
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Abb, J., Breuninger, H. & Kommerell, M. Prevalence of antimicrobial resistance ofStreptococcus pneumoniae in Southwest Germany as determined by the E test. Eur J Epidemiol 10, 621–623 (1994). https://doi.org/10.1007/BF01719582
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DOI: https://doi.org/10.1007/BF01719582