Abstract
Experiments are described demonstrating that experimental insemination with autologous or homologous sperm into the ventral prostate or bladder neck of outbred Zbar male rats induces intravesical precipitation or stones. These observations suggest that clinical conditions resulting in intravesical sperm may be contributory to bladder lithiasis in man and may have relevance to its prevalence in men vs. women.
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Ablin RJ, Stein-Werblowsky R. Toward understanding the etiology of prostate cancer (Abstract). Symposium of Immunoandrology, 2nd Pan American Congress, Mexico City, 26–30 January 1981.
Stein-Werblowsky R. On the etiology of cancer of the prostate. Eur Urol 1978; 4: 370–373.
Drach GW. Urinary Lithiasis. In Walsh PC, Gittes RF, Permutter AD, Stamey TA, eds., Campbell's urology, vol. 1, 5th ed. Philadelphia: WB Saunders, 1986: 1095–1187.
Smith LH. Pathogenesis of renal stones. Minerals Electrolytes Metabol 1987; 13: 214–219.
Sutor DJ. Epidemiology and composition. In Chisholm GD ed., Stones. London: Heinemann, 1980: 95–103.
Stein-Werblowsky R, Ablin RJ. Spermatozoal-induction of experimental lithiasis of the bladder (Abstract). Fed Proc 1991; 5: A1640.
Nelson GA, Scimeca JM Jr, Abee CA, Gardner WA. Intraprostatic spermatozoa in the squirrel monkey. Prostate 1988; 12: 321–324.
Nelson GA, Culberson DE, Gardner WA. Intraprostatic spermatozoa. Human Pathol 1988; 19: 541–544.
Casey MW, Ayers KM, Robinson FR. Urolithiasis. In Garner FM, Jones TC, eds., Pathology of laboratory animals. New York: Springer, 1978: 157–160.
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Stein-Werblowsky, R., Ablin, R.J. Sperm-induced urolithiasis in the rat. Eur J Epidemiol 10, 605–607 (1994). https://doi.org/10.1007/BF01719580
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DOI: https://doi.org/10.1007/BF01719580