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Liquid-phase combinatorial synthesis: In search of small-molecule enzyme mimics

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Summary

The applications, advantages and recent advances in liquid-phase combinatorial chemistry using poly(ethyleneglycol) as a soluble polymer support are reviewed. Our recent efforts towards the synthesis of peptide-based catalysts on polyethyleneglycol are reported. The screening of libraries of peptides for catalysis is discussed.

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Authors and Affiliations

  1. Departments of Molecular Biology and Chemistry, The Scripps Research Institute, 10550 North Torrey Pines Road, 92037, La Jolla, CA, USA

    Anthony M. Vandersteen, Hyunsoo Han & Kim D. Janda

  2. The Skaggs Institute of Chemical Biology, 10550 North Torrey Pines Road, 92037, La Jolla, CA, USA

    Anthony M. Vandersteen, Hyunsoo Han & Kim D. Janda

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  1. Anthony M. Vandersteen
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  2. Hyunsoo Han
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Vandersteen, A.M., Han, H. & Janda, K.D. Liquid-phase combinatorial synthesis: In search of small-molecule enzyme mimics. Mol Divers 2, 89–96 (1996). https://doi.org/10.1007/BF01718705

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