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Anti-EBNA1/anti-EBNA2 ratio decreases significantly in patients with progression of HIV infection

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Summary

Reactivation of EBV infection is common in immunocompromised individuals. We determined specific antibodies to EBV-encoded nuclear antigens (EBNA) 1 and 2 in 102 sera of HIV-infected individuals. Anti-EBNA1/anti-EBNA2 ratio (E1/E2) is less than 1 in chronic infection and exceeds 1 in healthy EBV-positive carriers. 52% of cases had E1/E2<1. E1/E2 decreased remarkably during the progression of HIV infection. Detectable HIV-Antigen, decline of CD4 + cell count and CD4 + /CD8 + ratio were correlated with an increasing prevalence of E1/E2 below 1. We conclude that determination of E1/E2 is useful in immunocompromised patients.

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Authors and Affiliations

  1. Abteilung Innere Medizin IV, Universitätskliniken des Saarlandes, Homburg/Saar, Federal Republic of Germany

    B. Winkelspecht

  2. Abteilung Virologie, Institut für Medizinische Mikrobiologie und Hygiene, Universitätskliniken des Saarlandes, Homburg/Saar, Federal Republic of Germany

    F. Grässer & N. Mueller-Lantzsch

  3. Abteilung Innere Medizin I, Universitätskliniken des Saarlandes, Homburg/Saar, Federal Republic of Germany

    H. W. Pees

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  1. B. Winkelspecht
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  2. F. Grässer
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  3. H. W. Pees
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  4. N. Mueller-Lantzsch
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Winkelspecht, B., Grässer, F., Pees, H.W. et al. Anti-EBNA1/anti-EBNA2 ratio decreases significantly in patients with progression of HIV infection. Archives of Virology 141, 857–864 (1996). https://doi.org/10.1007/BF01718160

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  • DOI: https://doi.org/10.1007/BF01718160

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