Summary
Plasma concentrations of free and sulfoconjugated catecholamines were measured in healthy infants and children under resting conditions. Free norepinephrine and epinephrine levels were up to three times higher in healthy children under 2 years than in adults, even under true resting conditions. In contrast, free dopamine concentrations of all age groups fell within the normal range for adults. The levels of sulfoconjugation were in the adult range.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
Abbreviations
- NE:
-
norepinephrine
- E:
-
epinephrine
- DA:
-
dopamine
References
Dalmaz Y, Peyrin L, Sann L, Dutruge J (1979) Age-related changes in catecholamine metabolites of human urine from birth to adulthood. J Neural Transm 46:153–174
Da Prada M, Zürcher G (1976) Simultaneous radioenzymatic determination of plasma and tissue adrenaline, noradrenaline and dopamine within the femtomol range. Life Sci 19:1161–1174
Da Prada M, Zürcher G (1979) Radioenzymatic assay of plasma and urinary catecholamines in man and various animal species: physiological and pharmacological applications. In: Albertini A, Da Prada M, Pescar BA (eds) Radioenzymatic assays of drugs and hormones in cardiovascular medicine. Elsevier, New York, pp 175–198
Eliot RJ, Lam R, Leake RD, Hobel CJ, Fisher DA (1980) Plasma catecholamine concentrations in infants at birth and during the first 48 hours of life. J Pediatrics 96:311–315
FitzGerald GA, Hossmann V, Hamilton CA, Reid JL, Davies DS, Dollery CT (1979) Interindividual variation in the kinetics of infused epinephrine. Clin Pharmacol Ther 26(6):669–675
Korn A, Da Prada M, Raffesberg W, Gasic S, Eichler HG (1988) The effect of moclobemide, a new reversible monoamine oxidase inhibitor on absorption and pressor effect of tyramine. J Cardiovasc Pharmacol 11:17–23
Kuchel O, Buu NT (1984) Conjugation of norepinephrine and other catecholamines. In: Ziegler MG, Lake CR (eds) Norepinephrine. Williams and Wilkins; Baltimore/London, pp 250–270
Planz G, Bieber J, Mencke HJ, v. Bernuth G (1983) Plasma catecholamines in children. Experientia 39:871
Planz G, Planz R (1981) Dissociation between duration of plasma catecholamine and blood pressure responses to beta-adrenergic blockade in normotensive subjects during physical exercise. Eur J Clin Pharmacol 19:83–88
Pluto R, Bürger P, Weicker H (1986) The physiological variability of catecholamine levels in plasma. Klin Wochenschr 64:625–632
Robertson D, Johnson GA, Robertson RM, Nies AS, Shand DG, Dates JA (1979) Comparative assessment of stimuli that release neuronal and adrenomedullary catecholamines in man. Circulation 59:637–643
Ziegler MG, Lake CR (eds) (1984) Norepinephrine. Williams and Wilkins; Baltimore/London, pp 250–270
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Eichler, I., Eichler, H.G., Rotter, M. et al. Plasma concentrations of free and sulfoconjugated dopamine, epinephrine, and norepinephrine in healthy infants and children. Klin Wochenschr 67, 672–675 (1989). https://doi.org/10.1007/BF01718028
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF01718028