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Wirkung von Caerulein auf Blutglukose, Seruminsulin, Glucagon, Prolaktin und Wachstumshormon vor und während einer oralen Glukosebelastung bei Gesunden und Diabetikern

Effect of caerulein on blood glucose, serum insulin, glucagon, prolactin and growth hormone before and after oral glucose load in healthy volunteers and diabetic patients

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Summary

Eleven healthy volunteers, five type I diabetics, and one type II diabetic man were examined. After an overnight fast caerulein (20 ng/kg) was injected intravenously and 60 min later an oral glucose tolerance test was performed with 100 g glucose in the normals and 25 g glucose in the diabetics. Blood pressure, pulse rate, blood glucose, serum insulin, glucagon, prolactin and growth hormone values were measured during the whole period of 240 min and compared with the same parameters in control tests in the same persons without caerulein application.

None of the measured parameters were significantly influenced by caerulein. It is therefore concluded that in contrast to the stimulation of the exocrine pancreas functions of the endocrine pancreas, the pituitary gland and glucose tolerance are unchanged after caerulein.

Zusammenfassung

Untersucht wurden 11 gesunde Personen, fünf Typ I und ein Typ II Diabetiker. Nach einer 12stündigen Fastendauer wurde Caerulein (20 ng/kg) i.v. injiziert und 60 Minuten später eine orale Glukosebelastung mit 100 g bei den Gesunden und 25 g Glukose bei den Diabetikern durchgeführt. Blutdruck, Puls, Blutglukose, Serum-Insulin, Glucagon, Prolaktin und Wachstumshormon wurden während der gesamten Testdauer von 240 min in regelmäßigen Abständen gemessen und mit den Werten einer Kontrolluntersuchung bei den gleichen Personen ohne Caerulein verglichen. Caerulein führte zu keiner signifikanten Änderung einer der gemessenen Parameter. — Während Caerulein die exokrine Pankreasfunktion stark stimuliert, hat dieses Decapeptid keinen Einfluß auf Glukosetoleranz und Funktionen des endokrinen Pankreas und der Hypophyse.

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  1. Med. Klinik Innenstadt d. Universität München, Ziemssenstr. 1, D-8000, München 2, Bundesrepublik Deutschland

    R. Landgraf, T. Eversmann & M. M. C. Landgraf-Leurs

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  1. R. Landgraf
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  2. T. Eversmann
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  3. M. M. C. Landgraf-Leurs
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Landgraf, R., Eversmann, T. & Landgraf-Leurs, M.M.C. Wirkung von Caerulein auf Blutglukose, Seruminsulin, Glucagon, Prolaktin und Wachstumshormon vor und während einer oralen Glukosebelastung bei Gesunden und Diabetikern. Klin Wochenschr 59, 539–543 (1981). https://doi.org/10.1007/BF01716454

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