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Diagnostic laparoscopy in patients with acute leukemia and suspected hepatic candidiasis

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Abstract

To assess the value of laparoscopy in the diagnosis of suspected hepatosplenic candidiasis in patients with acute leukemia, a retrospective analysis of 28 laparoscopies was conducted. In all but two cases, imaging of the liver showed focal lesions before laparoscopy. Diagnosis of hepatic candidiasis was established significantly more often when the biopsy was targeted at white nodules (in 12 of 22 laparoscopies) than when targeted randomly or at scars (0 of 6 laparoscopies) (p=0.017, chi-square test). Yeast was detected more often if the laparoscopy was performed during the three-week period after recovery from neutropenia (in 8 of 12 laparoscopies) than when performed later (in 4 of 16 laparoscopies) (p=0.028, chi-square test). In addition to the 12 laparoscopically diagnosed patients, eight (29%) patients were diagnosed with disseminatedCandida infection by other methods. In another eight (29%) patients the causative agent was not identified. No bleeding or other problems occurred after the laparoscopy. Laparoscopy-guided liver biopsy is most useful if biopsies are targeted to macroscopic lesions and if laparoscopy is performed soon after recovery from neutropenia.

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Authors and Affiliations

  1. Division of Haematology, Helsinki University Central Hospital, Haartmaninkatu 4, FIN-00290, Helsinki, Finland

    V. -J. Anttila & T. Ruutu

  2. Division of Infectious Diseases and Gastroenterology, Department of Medicine, Helsinki University Central Hospital, Haartmaninkatu 4, FIN-00290, Helsinki, Finland

    M. Färkkilä & P. Ruutu

  3. Department of Clinical Chemistry, Helsinki University Central Hospital, Haartmaninkatu 4, FIN-00290, Helsinki, Finland

    S. E. Jansson

  4. Department of Radiology, Helsinki University Central Hospital, Haartmaninkatu 4, FIN-00290, Helsinki, Finland

    M. Taavitsainen

  5. Laboratory of Mycology, Helsinki University Central Hospital, Haartmaninkatu 4, FIN-00290, Helsinki, Finland

    P. Koukila-Kähkölä

  6. Department of Bacteriology and Immunology, University of Helsinki, Finland

    S. -S. Kaukoranta-Tolvanen

  7. Department of Pathology, University of Helsinki, Finland

    S. Nordling

Authors
  1. V. -J. Anttila
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  2. M. Färkkilä
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  3. S. E. Jansson
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  4. M. Taavitsainen
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  5. S. -S. Kaukoranta-Tolvanen
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  6. S. Nordling
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  7. P. Koukila-Kähkölä
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  8. T. Ruutu
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  9. P. Ruutu
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Anttila, V.J., Färkkilä, M., Jansson, S.E. et al. Diagnostic laparoscopy in patients with acute leukemia and suspected hepatic candidiasis. Eur. J. Clin. Microbiol. Infect. Dis. 16, 637–643 (1997). https://doi.org/10.1007/BF01708552

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