Abstract
Cinchophen injected into the cerebral ventricle reacted with the hypothalamus somewhere in the vicinity of third ventricle, and produced a release of ACTH as indicated by a rise in peripheral plasma 11-OHCS concentration in the dog. The amount of cinchophen injected into the ventricle corresponds to about 1/600 of the dose required to produce the same effect by the intravenous route. Repeated intraventricular injections of cinchophen were effective in producing gastric erosions and ulcers at smaller doses than the intravenous one (1/100 and 1/400). Damage to the gastric wall might be due to a mechanism involving a localized portion of the hypothalamus and/or via a cerebral ventricle. Bilateral truncal vagotomy did not have any effect on chronic ulcer production. The cinchophen ulcerations were accompanied by an increase in plasma corticosteroids. The new experimental technique for producing peptic ulcer in dogs via a central neurohumoral mechanism is described.
Similar content being viewed by others
References
Churchill TP, Van Wagoner FH: Cinchophen poisoning. Proc Soc Exp Biol Med 28:581–582, 1931
Van Wagoner FH, Churchill TP: Production of gastric and duodenal ulcers in experimental cinchophen poisoning of dogs. Arch Pathol 14:860–869, 1932
Stalker LK, Bollman JL, Mann FC: Experimental peptic ulcer produced by cinchophen. Arch Surg 35:290–308, 1937
Ishihara K, Kawafuchi J, Kano K, Ishizaka I: Effect of pituitary stalk section on the development of cinchophen ulcer in the canine stomach with special reference to hypothalamo-neurohypophyseal system and adrenal gland. Okajima Fol Anat Jpn 28:477–488, 1956
Nagamachi Y, Ishihara K: Role of the hypothalamus in the pathogenesis of cinchophen-induced gastric ulcers in dogs. Am J Dig Dis 15:1083–1089, 1970
Ishihara K, Nagamachi Y: Experimental production of chronic peptic ulcer in dogs by hypothalamic implants of cinchophen. Recent Advances in Gastroenterology. The Proceeding of the 3rd World Congress of Gastroenterology, H Ueda (ed). Tokyo, Nankodo Press, Vol. 2, 1967, pp 137–141
Nagamachi Y: Effects of adrenaline injected into the hypothalamus and hypophysis on gastric secretion. Kitakanto Med J 14:373–383, 1964
Nagamachi Y: Experimental procedures for dog's hypothalamus and hypophysis by the method of transbuccal direct vision. Clin Physiol 1:367–372, 1971
Nagamachi Y: Gastric pepsin secretion by hypothalamo-pituitary-adrenal activation due to intrahypothalamic implantation of adrenaline. Am J Dig Dis 18:23–31, 1973
Mattingly D: A simple fluorimetric method for estimation of free 11-hydroxycorticoids in human plasma. J Clin Pathol 15:374–379, 1962
Bucher GR, Grossman MI, Ivy AC: A pepsin method: The role of dilution in the determination of peptic activity. Gastroenterology 5:501–511, 1945
Handa I: Plasma corticosterone concentration augmented after cinchophen administration and its mechanism. Kitakanto Med J 17:1–6, 1967
Ishihara K, Nagamachi Y: Hypothalamic control of cinchophen induced gastric lesions. 4th World Congress of Gastroenterology. Advance Abstracts. P Riis, P Anthonisen, H Baden (eds). Copenhagen, Denmark, 1970, p 25
Nagamachi Y: Experimental gastric ulcer and central nervous system with special reference to the ulcer etiology by central nervous system. Clin Physiol 2:357–371, 1972
Bollman JL, Stalker LK, Mann FC: Experimental peptic ulcer produced by cinchophen. Arch Intern Med 61:119–128, 1938
Varro V, Csernay L: Experimental production of peptic ulcer by administration of cinchophen. Pathophysiology of Peptic Ulcer. SC Skoryna (ed). Montreal, McGill University Press, 1963, pp 281–290
Simonds JP: Mode of origin of experimental gastric ulcer induced by cinchophen. Arch Pathol 26:44–50, 1938
Hueper WC: Cinchophen (Atophan), a critical review. Medicine 27:43–103, 1948
Sato H: Effects of autonomic blocking agents on gastric secretion and ulceration induced by cinchophen. Kitakanto Med J 10:541–553, 1960
Ishizaka I: Experimental investigation on cinchophen gastric ulcer. Kitakanto Med J 10:317–338, 1960
Hámori A, Nemes T, Hal T: Effect of prednisolone administration on the development of cinchophen ulcer. Recent Advances in Gastroenterology. The Proceeding of the 3rd World Congress of Gastroenterology, H Ueda (ed). Tokyo, Nankodo Press. Vol. 2. 1967, pp 137–141
Reah TG, Camb MB: Cinchophen poisoning. Lancet 2:504–509, 1932
Nagamachi Y: Bastric mucosal pepsin as a factor affecting experimentally induced gastric erosions in dogs. Jpn J Gastroenterol 69:1151–1162, 1972
Kirsner JB: Drug-induced peptic ulcer. Ann Intern Med 47:666–699, 1957
Ingle DJ, Prestrud MC, Li CH: Effects of administering adrenocorticotrophic hormone by continuous injection to normal rats. Am J Physiol 166:165–170, 1951
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Nagamachi, Y. New method of obtaining cinchophen ulcer in dogs. Digest Dis Sci 22, 761–768 (1977). https://doi.org/10.1007/BF01694505
Issue Date:
DOI: https://doi.org/10.1007/BF01694505